Presentations & Publications

“Pharmacokinetic-driven phase I study of DCC-2618 a pan-KIT and PDGFR inhibitor in patients (pts) with gastrointestinal stromal tumor (GIST) and other solid tumors.” ASCO 2017 Annual Meeting, Chicago, Il. Abstract# 2515

“Oncogenic BRaf Deletions That Function as Homodimers and Are Sensitive to Inhibition by Raf Dimer Inhibitor LY3009120”, Cancer Discovery 2016; Jan. online.

“Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.” Cancer Cell 2015; 28:384-98.

“DCC-2618 is a potent inhibitor of wild type and mutant KIT, including refractory Exon 17 D816 KIT mutations.” AACR 106th Annual Meeting, Philadelphia, PA. Cancer Res 75(15 Suppl); Abstract 2690

“Rebastinib potently inhibits function of perivascular TIE2 expressing macrophages in vitro and in vivo.” AACR 106th Annual Meeting, Philadelphia, PA. Cancer Res 75(15 Suppl): Abstract 397.

“Mechanisms of transendothelial migration by invasive breast carcinoma cells from patients.” AACR 106th Annual Meeting, Philadelphia, PA. Cancer Res 75(15 Suppl): Abstract 4112.

“Altiratinib (DCC-2701): a balanced inhibitor of MET, TIE2, and VEGFR2 kinases that exhibits broad anti-tumor and anti-angiogenic activities.” 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona, Spain.

“Identification of LY3009120 as a pan inhibitor of Raf isoforms and dimer with activity against BRaf or Ras mutant tumor cells and minimal paradoxical activation.” AACR Annual Meeting, San Diego, CA. Cancer Res 74(19 Suppl): Abstract DDT02-02.

“The specific FMS kinase inhibitor, DCC-3014, durably inhibits FMS kinase in vivo and blocks cancer bone invasiveness.” AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment Meeting, San Diego, CA. Cancer Res 75(1 Suppl): Abstract A53.

“Rebastinib in combination with eribulin ablates TIE2-expressing macrophages, reduces metastasis, and increases survival in the PyMT metastatic breast cancer model.” San Antonio Breast Cancer Symposium, San Antonio, TX 2013

“Use of μCT imaging in the PyMT breast cancer model to monitor lung metastasis development and determine therapeutic benefit in real time.” AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, Boston, MA. Mol Cancer Ther November 2013 12; B145

“Rebastinib and DCC-2701: Targeting of resistance mechanisms in cancer treatment.” 245th National American Chemical Society Symposium, New Orleans, LA 2013

“Rebastinib, a small molecule TIE2 kinase inhibitor, prevents primary tumor growth and lung metastasis in the PyMT breast cancer model.” AACR Special Conference on Tumor Invasion and Metastasis; San Diego, CA. Cancer Res February 1, 2013 73; B78

“Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036”, Cancer Cell, Volume 19, Issue 4, 556-568, April 2011

“Switch Control Pocket Inhibitors of p38-MAP Kinase. Durable Type II Inhibitors that do not Require Binding into the Canonical ATP Hinge Region”, Bioorg. Med. Chem Letters, Vol 20, Issue 19, 5793-5798, October 2010