Our Pipeline

Enabled by our proprietary drug discovery platform, we have developed a diverse pipeline of wholly-owned drug candidates.⁽¹⁾

Pipeline graphic is not for promotional use.

Pre-Clinical Phase 1 Phase 1b/2 Phase 3 Regulatory
Submission
Approved

Ripretinib

Broad Spectrum Inhibitor of KIT & PDGFRA

Ripretinib is an orally administered switch-control kinase inhibitor that was engineered to broadly inhibit KIT and PDGFRA mutated kinases by using a dual mechanism of action that regulates the kinase switch pocket and activation loop.

  • GIST ≥4ᵗʰ Line (INVICTUS Study)⁽¹⁾
  • GIST 2ⁿᵈ Line (INTRIGUE Study)
  • GIST Post-Imatinib in Combination with Binimetinib

Vimseltinib

Inhibitor of CSF1R

Vimseltinib is an investigational, orally administered, potent and highly selective switch-control kinase inhibitor designed to selectively bind to the CSF1R switch pocket.

 

  • Tenosynovial Giant Cell Tumor (TGCT)

Rebastinib

Inhibitor of TIE2

Rebastinib is an investigational, orally administered, potent and highly selective switch-control kinase inhibitor of the TEK tyrosine kinase, or TIE2, the receptor for angiopoietins ANG-1 and ANG-2, an important family of vascular growth factors.

  • Solid Tumors in Combination with Paclitaxel

DCC-3116

Inhibitor of ULK

DCC-3116 is an investigational, orally administered, potent and highly selective switch-control inhibitor of ULK kinase.

  • RAS/RAF Mutant Cancers in Combination with Trametinib

Updated as of May 2021; (1) Exclusive development and commercialization license with Zai Lab in Greater China for QINLOCK.