Career Opportunities

How to Apply

When an opportunity in which you are interested becomes available, please submit your resume or CV, cover letter with job code and salary requirements to the address below. All submissions will be evaluated. Interviews will be conducted for those applicants who most strongly fit our needs. If you are not contacted for an interview, your resume will remain on file and active for one year.

Open Positions

Associate Director, Medical Writing

Job #: 02-207

Job Title: Associate Director, Medical Writing

Role Summary:

Deciphera Pharmaceuticals, a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, is seeking an Associate Director of Medical Writing with experience in managing multidisciplinary drug development projects. The successful candidate will apply their medical writing skills to ongoing clinical-stage programs, assist in developing a consolidated multi-year budget for each program in collaboration with the functional groups and Finance, and regularly communicate project and program information to the Management Team.

This position will report to the VP of Regulatory Affairs and Quality at Deciphera’s corporate headquarters in Waltham, MA.

Key Responsibilities:

  • Provide Medical Writing leadership for clinical development programs and regulatory filings.
  • Serve as lead Medical Writer for key programs.
    • Documents include but are not limited to: Sections of clinical trial applications, INDs, Protocols and Protocol Amendments, Clinical Study Reports, Briefing documents, Investigator Brochures, Expert Reports, Scientific Manuscripts, clinical sections of New Drug Applications, and other documents as appropriate.
  • Coordinate with regulatory operations to make submissions to FDA and European regulatory authorities.
  • Coordinate medical writing support for programs with contract writers.
  • Provide leadership for medical writing processes, standards and initiatives.
  • Function as a strong technical leader and manager with excellent scientific, strategic, and customer focused leadership.
  • Partner with R&D team members to ensure completion of high quality and timely clinical documentation.

Basic Qualifications:

  • B.S. required.
  • 7+ years of related experience in biotech or pharmaceutical environment.
  • Equivalent combination of education and experience considered.
  • Must have strong scientific and operational background.

Preferred Qualifications:

  • M.S. or Ph.D. in biology or related discipline preferred

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for health care and/or dependent care.

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Senior/Principal SAS Programmer

Role Summary:
Deciphera Pharmaceuticals, a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, is seeking a Senior/Principal SAS Programmer. The Senior/Principal SAS Programmer will act as a lead programmer for Deciphera clinical studies.

This position may be filled at Senior or Principal level based on candidate’s skills/experience and will report to the Director of Biostatistics at Deciphera’s corporate headquarters in Waltham, MA.

Key Responsibilities:

  • Works collaboratively with other functions to ensure clarity, accuracy and consistency of case report forms (CRFs), develop and comply with project/study programming standards and specifications according to regulatory guidelines.
  • Programs for SDTM data mapping and creation of ADaM datasets and the corresponding specifications according to CDISC standards.
  • Programs TLFs for implementation of the statistical analysis plans and for AdHoc analysis in clinical trial of all phases.
  • Performs programming QC on TLFs.
  • Tracks clinical trial milestones and works with vendors for statistical reporting deliverables.
  • Maintains records for all assigned projects and archiving of trial/project analysis and associated documentation.
  • Understands and performs in accordance with regulatory standards, and drug development principles.
  • Responsible for the creation and accuracy of Regulatory submission data and clinical summary report package.
  • Plans, develops, tests, and documents SAS macros for programming efficiency.

Minimum Requirements

  • 8+ years in statistical programming within the Pharmaceutical industry
  • Strong understanding of clinical trial processes and statistical programming requirements for regulatory submissions.
  • Excellent SAS Software Programming skills, including Base SAS, SAS/STAT, SAS/GRAPH and macro development.
  • Ability to define and implement CDISC compliant SDTM and ADaM data and specifications.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plans, life insurance and a flexible spending account for health care and/or dependent care.

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Senior Scientist – Chemistry

Job #:  04-201

Role Summary:
Deciphera Pharmaceuticals, a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, is seeking a Senior Scientist – Chemistry.  The candidate will work in the drug discovery team to enhance the company pipeline of drugs to treat human diseases.

The successful candidate will be an experienced PhD chemist/medicinal chemist with 2+ years of experience.  This position will report to a Principal Investigator in the Lawrence, KS Research Facility.

Key Responsibilities:

  • Responsible for contributing scientifically and intellectually to Deciphera kinase inhibitor programs especially in the area of medicinal chemistry.
  • Responsible for design and implementation of synthetic routes to prepare proprietary small molecules for biological testing in assigned projects.
  • Responsible for tracking structure activity relationships and optimizing potency, selectivity and pharmaceutical properties of small molecules for research programs.
  • Responsibility for interdisciplinary engagement with others in the organization and also with various CROs in the areas of kinase inhibitor switch control technology, structure-based drug design, kinase biochemistry, kinase cellular biology, and pharmacology/pharmaceutics.
  • Responsible for adhering to corporate policies including safety, FDA compliance and regulatory matters.
  • Responsible for generating reports and presentations as required by the organization, and providing input on intellectual property activities.
  • Values other people and promotes the welfare of the organization and colleagues.
  • Responsible for adhering to corporate policies including safety, FDA compliance and regulatory matters.

 Basic Qualifications:

  • Ph.D. in organic or medicinal chemistry with 2+ years of industrial experience in synthetic organic chemistry / drug discovery.
  • High level of creativity and productivity with strong synthetic chemistry problem solving skills.
  • Demonstrated excellence in organic synthesis, conversant with the current literature.
  • In-depth knowledge and hands-on experience with a wide range of techniques in synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.).
  • Experience using the concepts and tools of structure-based drug design is a plus.
  • Excellent oral and written communication skills.
  • Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team and maintain effective working relationships.
  • Effective oral and scientific/technical writing communication skills.
  • Demonstrated proficiency using MS Office applications is required.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Scientist II – Chemistry

Job #:  04-200

Role Summary:
Deciphera Pharmaceuticals, a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, is seeking a Scientist II – Chemistry.  The candidate will work in the drug discovery team to enhance the company pipeline of drugs to treat human diseases.

The successful candidate will be an experienced Master Level Chemist with 3+ years of experience.  This position will report to a Principal Investigator in the Lawrence, KS research facility.

Key Responsibilities:

  • Responsible for design and implementation of synthetic routes to prepare proprietary small molecules for biological testing.
  • Responsible for tracking structure activity relationships and optimizing potency, selectivity and pharmaceutical properties of small molecules for research programs.
  • Responsible for designing new and improved analogs within chemical series.
  • Responsible for adapting synthetic routes to enable more efficient preparation of small molecules on a 10-100 gram scale.
  • Work effectively in a team environment, communicating and planning research with other chemists, molecular biologists, and pharmacologists also working on project.
  • Prepares written reports, experimentals for patents, and other reports as required
  • Values other people and promotes the welfare of the organization and colleagues.
  • Responsible for adhering to corporate policies including safety, FDA compliance and regulatory matters.

Basic Qualifications:

  • M.S. in organic or medicinal chemistry with 3+ years of industrial or B.S. with 5+ years of experience in synthetic organic chemistry / drug discovery.
  • Must possess a good working knowledge of organic synthesis and medicinal chemistry.
  • In-depth knowledge and hands-on experience with a wide range of techniques used in synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.).
  • Capable of independent design/refinement of synthetic routes considering the needs of the project (e.g., analogue generation, scale-up).
  • Self-aware; will seek input from others on ideas and problem-solving; uses others as a resource.
  • Excellent oral and written communication skills.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

 

 

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Vendor Manager

Job Code:  02-201

Location: Waltham, MA

The Vendor Manager is responsible for overseeing the process of managing external service providers including CRO’s, Investigator Sites and other third party vendors to assist Deciphera in the successful conduct of clinical.  This position is responsible for managing/tracking the performance of vendor activities. This position will require an excellent knowledge of clinical trial management, global supplier oversight, regulatory requirements, clinical service suppliers, as well as team-based management practices.  This position will report to the VP, Clinical Operations in the Waltham, MA office.

Specific Duties assigned to the Vendor Manager are as follows:

1) Vendor Selection and Contract Negotiation
  • Meet with project teams to gain an understanding of scope of work and the priorities of the various projects.
  • Guide project team through the outsourcing process and give appropriate suggestions and advice on the best approach / best practices.
  • Facilitate the Request for Proposal process and Vendor selection and negotiation.
  • Coordinate with Legal and Finance for documents related to the outsourcing process; e.g. Master Service Agreements, Work Orders, transfer of obligations chart, payment schedule, etc.
  • Formulation and harmonization of project scopes, plans, strategies and budgets across all outsourced activities.
  • Guide and participate with project teams in the evaluation, selection, and negotiation of vendor contracts.
  • Liaise with the project team to develop, negotiate and finalize the Work Order for each contract.
2) Vendor Management
  • Perform as central point of contact amongst external vendors as well as internal stakeholders.
  • Improve established Vendor relations via implementation/oversight of Key Performance Indicators (KPI’s) or Service Level Agreements (SLA’s) or metrics.
  • Plan and facilitate scheduling and organization of “kick-off” meetings with vendors and governance meetings.
  • Facilitate formulation of workflow processes, hand-offs, methods/process and policies for executing vendor services.
  • Facilitate and/or participate in team meetings with vendors.
  • Support the project teams to assure the quality and timeliness of deliverables for each vendor.
  • Facilitate development of Vendor Management Plan.
  • Monitor, manage and report on vendor performance.
  • Facilitate the resolution of issues and conflicts with internal study team that may arise during the course of a service provider engagement.
  • Ensure key deliverable are met including identification and management of risk assessment.
  • Discuss and develop change order implementation strategies for projects.
  • Negotiate changes to specifications, budgets, payment schedules, relationship management plans and other documents that control the activities and performance of vendors.
  • Ensure smooth and effective communication between the internal study team and coordination of interdependent vendor commitments to meet study objectives.
  • Facilitate the closure of each study/contract with the vendor, including a mutual assessment of performance.
3) Site Management
  • Negotiate and finalize global clinical site agreements and related Investigator grants and/or act as an escalation point.
4)  Other requirements
  • Support strategic planning activities and implementation of strategic decisions into operational plans.

Education, Special Skills and Experience

  • Bachelor’s degree required with at 5+ years experience in clinical operations with a minimum of 2 years in vendor management.
  • In-depth knowledge and understanding of the drug development process.
  • Demonstrated interaction, creativity and problem solving skills with the management of clinical service providers, excellent oral and written communication skills. Ability to manage multiple programs and processes simultaneously.
  • Proven ability to work with clinical development teams in the specification, selection and oversight of outsourced clinical services.
  • Proven ability to build relationships and manage expectations with key clinical service providers who represent single or multiple functions.
  • Internal customer management, supplier relationship building, supplier expectation management, influence of peers, team effectiveness and enhancement, timeline management, proactive problem solving ability, resource planning, ability to develop trust, shared goals and values.
  • The candidate should be detail oriented, identify issues and assist in problem solving in a timely manner.
  • Computer skills: standard MS Office Suite applications required including MS Project.
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E-mail

All e-mails should include the specific job code, resumes should be attached as PDF’s and sent to  careers@deciphera.com.
No phone calls please