Career Opportunities

How to Apply

When an opportunity in which you are interested becomes available, please submit your resume or CV, cover letter with job code and salary requirements to the address below. All submissions will be evaluated. Interviews will be conducted for those applicants who most strongly fit our needs. If you are not contacted for an interview, your resume will remain on file and active for one year.

Open Positions

Senior Scientist – Chemistry

Job #:  04-201

Role Summary:
Deciphera Pharmaceuticals, a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, is seeking a Senior Scientist – Chemistry.  The candidate will work in the drug discovery team to enhance the company pipeline of drugs to treat human diseases.

The successful candidate will be an experienced PhD chemist/medicinal chemist with 2+ years of experience.  This position will report to a Principal Investigator in the Lawrence, KS Research Facility.

Key Responsibilities:

  • Responsible for contributing scientifically and intellectually to Deciphera kinase inhibitor programs especially in the area of medicinal chemistry.
  • Responsible for design and implementation of synthetic routes to prepare proprietary small molecules for biological testing in assigned projects.
  • Responsible for tracking structure activity relationships and optimizing potency, selectivity and pharmaceutical properties of small molecules for research programs.
  • Responsibility for interdisciplinary engagement with others in the organization and also with various CROs in the areas of kinase inhibitor switch control technology, structure-based drug design, kinase biochemistry, kinase cellular biology, and pharmacology/pharmaceutics.
  • Responsible for adhering to corporate policies including safety, FDA compliance and regulatory matters.
  • Responsible for generating reports and presentations as required by the organization, and providing input on intellectual property activities.
  • Values other people and promotes the welfare of the organization and colleagues.
  • Responsible for adhering to corporate policies including safety, FDA compliance and regulatory matters.

 Basic Qualifications:

  • Ph.D. in organic or medicinal chemistry with 2+ years of industrial experience in synthetic organic chemistry / drug discovery.
  • High level of creativity and productivity with strong synthetic chemistry problem solving skills.
  • Demonstrated excellence in organic synthesis, conversant with the current literature.
  • In-depth knowledge and hands-on experience with a wide range of techniques in synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.).
  • Experience using the concepts and tools of structure-based drug design is a plus.
  • Excellent oral and written communication skills.
  • Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team and maintain effective working relationships.
  • Effective oral and scientific/technical writing communication skills.
  • Demonstrated proficiency using MS Office applications is required.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Scientist II – Chemistry

Job #:  04-200

Role Summary:
Deciphera Pharmaceuticals, a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, is seeking a Scientist II – Chemistry.  The candidate will work in the drug discovery team to enhance the company pipeline of drugs to treat human diseases.

The successful candidate will be an experienced Master Level Chemist with 3+ years of experience.  This position will report to a Principal Investigator in the Lawrence, KS research facility.

Key Responsibilities:

  • Responsible for design and implementation of synthetic routes to prepare proprietary small molecules for biological testing.
  • Responsible for tracking structure activity relationships and optimizing potency, selectivity and pharmaceutical properties of small molecules for research programs.
  • Responsible for designing new and improved analogs within chemical series.
  • Responsible for adapting synthetic routes to enable more efficient preparation of small molecules on a 10-100 gram scale.
  • Work effectively in a team environment, communicating and planning research with other chemists, molecular biologists, and pharmacologists also working on project.
  • Prepares written reports, experimentals for patents, and other reports as required
  • Values other people and promotes the welfare of the organization and colleagues.
  • Responsible for adhering to corporate policies including safety, FDA compliance and regulatory matters.

Basic Qualifications:

  • M.S. in organic or medicinal chemistry with 3+ years of industrial or B.S. with 5+ years of experience in synthetic organic chemistry / drug discovery.
  • Must possess a good working knowledge of organic synthesis and medicinal chemistry.
  • In-depth knowledge and hands-on experience with a wide range of techniques used in synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.).
  • Capable of independent design/refinement of synthetic routes considering the needs of the project (e.g., analogue generation, scale-up).
  • Self-aware; will seek input from others on ideas and problem-solving; uses others as a resource.
  • Excellent oral and written communication skills.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

 

 

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Junior Medical Writer

Job Code: 02-203

Location: Waltham, MA

Position Overview

The Junior Medical Writer researches, writes, and edits clinical regulatory documents that may be submitted to Investigational sites, as well as the Food and Drug Administration and other global health authorities for submission and publication.

Key Accountabilities / Responsibilities

  • Author, co-author, critically edit, and format clinical regulatory documents, which include, but are not limited to: clinical study protocols, clinical study reports (CSRs), safety narratives, investigator brochures (IBs), development safety update reports (DSURs), and other regulatory documents.
  • Assist in the development of medical writing timelines for assigned projects and collaborate with medical writing manager to ensure timelines are met.
  • Lead and facilitate medical writing project meetings.
  • Maintain subject area expertise related to the company’s investigational products, disease indications, and regulatory guidelines.
  • Interact effectively with other functions, both internal and external (including but not limited to Regulatory, Clinical Research and Development, Clinical Operations, Data Management, Statistics, Safety, and nonclinical).
  • Support the development of medical writing processes, standard operating procedures, work instructions, and templates.
  • Willingness to perform miscellaneous job-related duties as assigned and accept new responsibilities as needed.

Minimum Requirements

  • Bachelor’s degree in a scientific field or an Advanced degree (Ph.D., PharmD, Masters) is preferred with previous medical writing responsibilities
  • 1 year of experience in medical writing.
  • Position is 4 days onsite/1 day working remotely.

Preferred Knowledge, Skills, and Abilities

  • Experience in the pharmaceutical or biotechnology industry is desired.
  • Knowledge of overall drug development, drug pre-marketing and marketing processes.
  • Knowledge of industry guidelines, standards, and regulations.
  • Excellent communication skills, both written and oral.
  • Excellent ability to interpret and present scientific and clinical trial data and understand statistical analyses.
  • Meticulous attention to detail.
  • Effective collaborator with ability to foster strong working relationships and build consensus among colleagues on cross-functional teams, both internally and externally.
  • Flexibility in meeting the changing demands of each project, as well as the ability to handle a variety of projects simultaneously.
  • Proficiency with Microsoft Office, in particular Word and PowerPoint.

 

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Vendor Manager

Job Code:  02-201

Location: Waltham, MA

The Vendor Manager is responsible for overseeing the process of managing external service providers including CRO’s, Investigator Sites and other third party vendors to assist Deciphera in the successful conduct of clinical.  This position is responsible for managing/tracking the performance of vendor activities. This position will require an excellent knowledge of clinical trial management, global supplier oversight, regulatory requirements, clinical service suppliers, as well as team-based management practices.  This position will report to the VP, Clinical Operations in the Waltham, MA office.

Specific Duties assigned to the Vendor Manager are as follows:

1) Vendor Selection and Contract Negotiation
  • Meet with project teams to gain an understanding of scope of work and the priorities of the various projects.
  • Guide project team through the outsourcing process and give appropriate suggestions and advice on the best approach / best practices.
  • Facilitate the Request for Proposal process and Vendor selection and negotiation.
  • Coordinate with Legal and Finance for documents related to the outsourcing process; e.g. Master Service Agreements, Work Orders, transfer of obligations chart, payment schedule, etc.
  • Formulation and harmonization of project scopes, plans, strategies and budgets across all outsourced activities.
  • Guide and participate with project teams in the evaluation, selection, and negotiation of vendor contracts.
  • Liaise with the project team to develop, negotiate and finalize the Work Order for each contract.
2) Vendor Management
  • Perform as central point of contact amongst external vendors as well as internal stakeholders.
  • Improve established Vendor relations via implementation/oversight of Key Performance Indicators (KPI’s) or Service Level Agreements (SLA’s) or metrics.
  • Plan and facilitate scheduling and organization of “kick-off” meetings with vendors and governance meetings.
  • Facilitate formulation of workflow processes, hand-offs, methods/process and policies for executing vendor services.
  • Facilitate and/or participate in team meetings with vendors.
  • Support the project teams to assure the quality and timeliness of deliverables for each vendor.
  • Facilitate development of Vendor Management Plan.
  • Monitor, manage and report on vendor performance.
  • Facilitate the resolution of issues and conflicts with internal study team that may arise during the course of a service provider engagement.
  • Ensure key deliverable are met including identification and management of risk assessment.
  • Discuss and develop change order implementation strategies for projects.
  • Negotiate changes to specifications, budgets, payment schedules, relationship management plans and other documents that control the activities and performance of vendors.
  • Ensure smooth and effective communication between the internal study team and coordination of interdependent vendor commitments to meet study objectives.
  • Facilitate the closure of each study/contract with the vendor, including a mutual assessment of performance.
3) Site Management
  • Negotiate and finalize global clinical site agreements and related Investigator grants and/or act as an escalation point.
4)  Other requirements
  • Support strategic planning activities and implementation of strategic decisions into operational plans.

Education, Special Skills and Experience

  • Bachelor’s degree required with at 5+ years experience in clinical operations with a minimum of 2 years in vendor management.
  • In-depth knowledge and understanding of the drug development process.
  • Demonstrated interaction, creativity and problem solving skills with the management of clinical service providers, excellent oral and written communication skills. Ability to manage multiple programs and processes simultaneously.
  • Proven ability to work with clinical development teams in the specification, selection and oversight of outsourced clinical services.
  • Proven ability to build relationships and manage expectations with key clinical service providers who represent single or multiple functions.
  • Internal customer management, supplier relationship building, supplier expectation management, influence of peers, team effectiveness and enhancement, timeline management, proactive problem solving ability, resource planning, ability to develop trust, shared goals and values.
  • The candidate should be detail oriented, identify issues and assist in problem solving in a timely manner.
  • Computer skills: standard MS Office Suite applications required including MS Project.
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Associate Director, Medical Science and Drug Development

Job Code:  02-202

Location: Waltham, MA

Reports to: VP, Clinical Development

Objectives:

Deciphera Pharmaceuticals is inspired to improve treatment for patients with cancer by designing kinase inhibitor therapies that target the hallmarks of cancer biology and tumors that are resistant to conventional kinase inhibitors. We are in the midst of significant expansion of our clinical trial activities with further growth planned in number of trials over the next 2 years.  The Associate Director, Medical Science and Drug Development will be responsible for analytical work and communications related to Medical Affairs and Drug Development of Deciphera’s clinical drug development program for genetically-defined cancers and immunooncology program. He or she will work in cross-functional teams to assure the highest standards of clinical drug development and GCP.

  • Support of clinical aspects of trial documents including protocol, IB and ICF development.
  • Support for medical aspects of regulatory and external communications documents.
  • Support of medical review of clinical trial data.
  • Support of translational, genomic, diagnostic and pharmacogenomic objectives of clinical trials.
  • Contributor to pharmacovigilance review of clinical trial data.

Accountabilities:

  • Analysis and monitoring of clinical and pharmacodynamic data in close partnership with data management.
  • Analysis of translational medicine, pharmacogenomic and biomarker data based on guidance of VP, Translational Medicine.
  • Safety data review and analysis for signal detection.
  • Support of interpretation of clinical trial data.
  • Contributor or author of medical affairs documents and communications to other audiences.
  • Monitoring of competitor activities and data.

Specific responsibilities include, but are not limited to:

  • Close collaboration with data management on coding and data cleaning together with Clinical Operations.
  • Medical writing of clinical sections in regulatory documents not limited to IND submission, IND annual updates, study protocols, investigator brochures, briefing documents, and other study-relevant documents like patient informed consent documents.
  • Reporting of clinical trial data that meet the standards of excellence for ethics, scientific merit, and regulatory compliance.
  • Writing manuscripts, publications or other documents intended for external audiences.
  • Support or preparation of data interpretation and clinical trial reports.
  • Contribute in an active and ongoing manner to the scientific, clinical and commercial development of current and future product candidates.
  • Support of Strategic or Clinical Advisory Boards.
  • Responsible for or support of Medical Affairs activities and collaboration with Patient Advocacy groups.

Education, Competencies and Skills:

  • Required: Ph.D., PharmD or comparable advanced degree, ideally with experience in a major pharmaceutical and/or biotech company.
  • Experience in data analysis and / or drug development.
  • 1-3 years of biopharmaceutical industry experience preferred.
  • Strong interpersonal, organization, planning and communication (oral and written) skills.
  • Knowledge of clinical development would accelerate professional development.
  • An entrepreneurial and hands-on attitude and highly self-motivated.

Deciphera Pharmaceuticals offer competitive compensation and benefits.

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E-mail

All e-mails should include the specific job code, resumes should be attached as PDF’s and sent to  careers@deciphera.com.
No phone calls please