How to Apply

When an opportunity in which you are interested becomes available, please submit your resume and cover letter with job code and salary requirements to the address below. All submissions will be evaluated. Interviews will be conducted for those applicants who most strongly fit our needs. If you are not contacted for an interview, your resume will remain on file and active for one year.


E-mail

All e-mails should include the specific job code in the subject line, resumes should be attached as PDF’s and sent to careers@deciphera.com.
No phone calls please.


Open Positions

Scientist – Biological Sciences (Lawrence, Kansas)

Job #: 04-219

Job Title: Scientist – Biological Sciences  

Location: Lawrence, KS

Company Overview:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently have three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside in Waltham, Massachusetts.

This position is located in our state-of-the-art research facility near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

  • Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
  • A diverse and multi-disciplinary workforce
  • Dedicated and talented people who are passionate about achieving excellence in all they do
  • A work environment that allows you to balance your priorities
  • Above all else, a commitment to the patients we serve

This position will report to the Principal Investigator – Biological Sciences in the Lawrence, KS research facility.

Key Responsibilities:

  • Perform primary screening of small molecules utilizing cell-based assays.  Primary responsibility will be in the area of screening small molecule kinase inhibitors
  • Perform routine mammalian cell culture
  • Together with supervisor, responsible for validating new biochemical or molecular biology-based assays and trouble-shooting when needed to establish reliable screening platforms
  • Work in a team environment to design and implement assays and experiments which test hypotheses and evaluate mechanisms of kinase inhibitors
  • Track and record data into corporate database
  • Generate reports and presentations as required by the organization
  • Effectively work in a team environment: communicate and plan research with other chemists, biologists, and pharmacologists also working on the project
  • Adhere to corporate policies including safety, FDA compliance and regulatory matters
  • Values other people and promotes the welfare of the organization and colleagues
  • Perform other duties as requested

Basic Qualifications:

  • BS or MS in Biochemistry or related field with 0-5 years of industry experience
  • Good knowledge and laboratory experience with enzyme and cellular biology techniques (Flow cytometry, Western blot, etc.)
  • Effective oral and scientific/technical writing communication skills
  • Demonstrated proficiency using MS Office applications

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Senior Scientist – Biological Sciences (Lawrence, Kansas)

Job #: 04-218

Job Title:  Senior Scientist – Biological Sciences  

Location: Lawrence, KS

Company Overview:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently have three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside in Waltham, Massachusetts.

This position is located in our state-of-the-art research facility near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

  • Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
  • A diverse and multi-disciplinary workforce
  • Dedicated and talented people who are passionate about achieving excellence in all they do
  • A work environment that allows you to balance your priorities
  • Above all else, a commitment to the patients we serve

This position will report to the Principal Investigator – Biological Sciences in the Lawrence, KS research facility.

Key Responsibilities:

  • Validate new molecular biology and cell-based assays needed to understand activities of kinase inhibitors against cancer cells and cells found in the tumor microenvironment
  • Perform routine cell-based screening assays, including ELISA, cell proliferation, apoptosis and other methods
  • Analyze ex vivo samples from studies performed at CROs
  • Explore potential biomarker assays
  • Track and record data into corporate database and notebooks
  • Participate in the preparation of scientific abstracts and manuscripts
  • Generate reports and create presentations as required by the organization
  • Effectively work in a team environment: communicate and plan research with others also working on the project
  • Adhere to corporate policies including safety, FDA compliance and regulatory matters
  • Able to independently work in a fast-paced environment
  • Values other people and promotes the welfare of the organization and colleagues
  • Perform other research duties when requested

Basic Qualifications:

  • Ph.D. in biochemistry or related field with 2-5 years of industrial experience or Masters in biochemistry or related field with 10+ years of industrial experience
  • Good knowledge and experience with a wide range of molecular and cellular biology techniques (ELISA, flow cytometry, Western blot, CRISPR and si/shRNA)
  • Experience with medium throughput (96 and 384-well) cell-based screening assays employing a variety of readouts
  • Familiarity with genome databases, protein data bank and other relevant databases
  • Effective oral and scientific/technical writing communication skills
  • Demonstrated proficiency using MS Office applications and other software (e.g. Prism) is required

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Scientist – Enzymology (Lawrence, Kansas)

Job #: 04-217

Job Title: Scientist – Enzymology

Location: Lawrence, KS

Company Overview:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently have three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside in Waltham, Massachusetts.

This position is located in our state-of-the-art research facility near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

  • Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
  • A diverse and multi-disciplinary workforce
  • Dedicated and talented people who are passionate about achieving excellence in all they do
  • A work environment that allows you to balance your priorities
  • Above all else, a commitment to the patients we serve

This position will report to the Senior Scientist – Enzymology in the Lawrence, KS research facility.

Key Responsibilities:

  • Perform routine drug screening assays for kinase inhibitors
  • Quality control of high throughput screening equipment
  • Together with supervisor, responsible for validating new biochemical assays and troubleshooting when needed to establish reliable screening platforms
  • Track and record data into corporate database and notebooks
  • Generate reports and create presentations as required by the organization
  • Effectively work in a team environment: communicate and plan research with others also working on the project
  • Adhere to corporate policies including safety, FDA compliance and regulatory matters
  • Values other people and promotes the welfare of the organization and colleagues
  • Perform other research duties when requested

Basic Qualifications:

  • BS or MS in Biochemistry or related field with 0-5 years of industry experience
  • Good knowledge and laboratory experience with enzyme and cellular biology techniques (Flow cytometry, Western blot, etc.)
  • Effective oral and scientific/technical writing communication skills
  • Demonstrated proficiency using MS Office applications

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Manager/Senior Manager, Internal Communications

Job #: 03-240

Job Title: Manager/Senior Manager, Internal Communications

Location: Waltham, MA

Company Summary:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

  • providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
  • a diverse and multi-disciplinary workforce
  • dedicated and talented people who are passionate about achieving excellence in all they do
  • a work environment that allows you to balance your priorities
  • above all else, a commitment to the patients we serve

Position Summary:

We are seeking a Manager/Senior Manager, Internal Communications with high energy and enthusiasm, who possesses strategic and creative communications expertise across a broad range of Human Resources, business, and employer branding communications programs.

This position will report directly to the Sr. Director, HR Operations with a dotted line reporting relationship to the Vice President, Investor Relationsand be located in the Waltham, MA office.

Key Responsibilities:

  • Create and manage internal communications corporate calendar; collaborate across the organization on the development of content for weekly communications, digital screens, all-employee meetings, other planned communications that facilitate employee connection to our goals and mission.
  • Effectively engage business leads across the organization to create effective and engaging internal communications campaigns for various business initiatives.
  • Drive the integration and adoption of multi-channel communications, integrating new media, technologies, etc., as appropriate, to help communicate messages to our rapidly expanding employee base.
  • Partner with IT and functional business owners to develop and optimize an Intranet platform, including the development of strategies to ensure ongoing maintenance.
  • Build and leverage online employee feedback channels, monitor in real-time, and analyze data to improve communications channels, delivery and frequency.
  • Ensure internal communications messages are consistent across all mediums and consistent with external communication messages.
  • Assist with planning of company events to drive employee engagement and alignment to corporate goals.
  • Assist with external communications initiatives, as needed, including company announcements, implementing content on corporate digital channels, etc.

Required Qualifications:

  • Bachelor’s degree required.
  • 5+ years’ experience in communications, with background in internal communications, preferably in the healthcare or life sciences industries.
  • Public relations experience a plus.
  • Experience with facilitating internal communications at high growth, multi-site organizations.
  • Ability to prioritize simultaneous responsibilities and/or projects
  • Outstanding written and verbal communications skills.
  • Strong interpersonal skills with proven ability to be a collaborative partner.
  • Skilled expertise with various digital mediums, applications and technology platforms including Instagram, Sharepoint, InDesign, Adobe, Powerpoint.
  • Willingness to think creatively and suggest new communications initiatives and channels to achieve communications objectives.
  • A ‘roll-up-the sleeves’ attitude to execute and ability to succeed in a fast-paced environment with multiple, competing priorities.
  • Graphic design and video editing skills a plus.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Scientist – Chemistry (Lawrence, Kansas)

Job #: 04-216

Job Title: Scientist – Chemistry

Location: Lawrence, KS

Company Overview:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently have three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside in Waltham, Massachusetts.

This position is located in our state-of-the-art research facility near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

  • Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
  • A diverse and multi-disciplinary workforce
  • Dedicated and talented people who are passionate about achieving excellence in all they do
  • A work environment that allows you to balance your priorities
  • Above all else, a commitment to the patients we serve

Role Summary:

The Scientist – Chemistry will work in the drug discovery team to enhance the company pipeline of drugs to treat human diseases.

The successful candidate will be an experienced Master Level Chemist with 2+ or B.S. with 5+ years of experience.  This position will report to a Principal Investigator in the Lawrence, KS research facility.

Key Responsibilities:

  • Responsible for the synthesis of small molecule kinase inhibitors
  • Work effectively in a team environment, communicating and planning research with other chemists working on their respective project
  • Prepare written reports, experimentals for patents, and other reports as required
  • Values other people and promotes the welfare of the organization and colleagues
  • Adhere to corporate policies including safety, FDA compliance and regulatory matters

Basic Qualifications:

  • M.S. in organic or medicinal chemistry with 2+ years of industrial or B.S. with 5+ years of experience in synthetic organic chemistry / drug discovery
  • Must possess a good working knowledge of organic synthesis and medicinal chemistry
  • Good knowledge and experience with a wide range of techniques used in organic synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.)
  • Capable of setting up multiple reactions and working independently in an organic chemistry lab setting
  • Self-aware; will seek input from others on ideas and problem-solving; uses others as a resource
  • Excellent oral and written communication skills

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Senior Scientist – Chemistry (Lawrence, Kansas)

Job #: 04-215

Job Title: Senior Scientist – Chemistry

Location: Lawrence, KS

Company Overview:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently have three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside in Waltham, Massachusetts.

This position is located in our state-of-the-art research facility near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

  • Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
  • A diverse and multi-disciplinary workforce
  • Dedicated and talented people who are passionate about achieving excellence in all they do
  • A work environment that allows you to balance your priorities
  • Above all else, a commitment to the patients we serve

Role Summary:

The Senior Scientist – Chemistry will work in the drug discovery team to enhance the company pipeline of drugs to treat human diseases.   

The successful candidate will be an experienced PhD chemist/medicinal chemist with 2+ years of experience.  This position will report to a Principal Investigator in the Lawrence, KS research facility.   

Key Responsibilities:

  • Contribute scientifically and intellectually to Deciphera kinase inhibitor programs especially in the area of medicinal chemistry
  • Design and implement synthetic routes to prepare proprietary small molecules for biological testing in assigned projects
  • Track structure activity relationships and optimizing potency, selectivity and pharmaceutical properties of small molecules for research programs
  • Manage interdisciplinary engagement with others in the organization and with various CROs in the areas of kinase inhibitor switch control technology, structure-based drug design, kinase biochemistry, kinase cellular biology, and pharmacology/pharmaceutics
  • Generate reports and presentations as required by the organization, and providing input on intellectual property activities
  • Adhere to corporate policies including safety, FDA compliance and regulatory matters
  • Values other people and promotes the welfare of the organization and colleagues

Basic Qualifications:

  • Ph.D. in organic or medicinal chemistry with 2+ years of industrial experience in synthetic organic chemistry / drug discovery
  • High level of creativity and productivity with strong synthetic chemistry problem solving skills
  • Demonstrated excellence in organic synthesis, conversant with the current literature
  • In-depth knowledge and hands-on experience with a wide range of techniques in synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.)
  • Experience using the concepts and tools of structure-based drug design is a plus
  • Excellent oral and written communication skills
  • Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team and maintain effective working relationships
  • Effective oral and scientific/technical writing communication skills
  • Demonstrated proficiency using MS Office applications is required

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Principal Investigator – Chemistry (Lawrence, Kansas)

Job #: 04-214

Job Title: Principal Investigator – Chemistry

Location: Lawrence, KS

Company Overview:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently have three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside in Waltham, Massachusetts.

This position is located in our state-of-the-art research facility near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

  • Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
  • A diverse and multi-disciplinary workforce
  • Dedicated and talented people who are passionate about achieving excellence in all they do
  • A work environment that allows you to balance your priorities
  • Above all else, a commitment to the patients we serve

Role Summary:

The Principal Investigator – Chemistry will be an experienced PhD chemist/medicinal chemist with 7+ years of experience and will work in the drug discovery team to enhance the company pipeline of drugs to treat human diseases.

This position will report to the Chief Scientific Officer at Deciphera’s research facility located in Lawrence, KS

Key Responsibilities:

  • Contribute scientifically and intellectually to Deciphera kinase inhibitor programs especially in the area of medicinal chemistry
  • Design and implement synthetic routes to prepare proprietary small molecules for biological testing in assigned projects
  • Develop new chemical matter and pharmacophores for Deciphera’s proprietary kinase inhibitors
  • May lead a small group of medicinal chemists
  • Track structure activity relationships and optimize potency, selectivity and pharmaceutical properties of small molecules for research programs
  • Lead interdisciplinary engagement with others in the organization and also with various CROs in the areas of kinase inhibitor switch control technology, structure-based drug design, kinase biochemistry, kinase cellular biology, and pharmacology/pharmaceutics
  • Generate reports and presentations as required by the organization, and providing input on intellectual property activities
  • Adhere to corporate policies including safety, FDA compliance and regulatory matters
  • Value other people and promote the welfare of the organization and colleagues


Basic Qualifications:

  • Ph.D. in organic or medicinal chemistry with 7+ years of industrial experience in synthetic organic chemistry / drug discovery
  • Excellent understanding of all aspects of medicinal chemistry (physiochemical properties, ADME, PK/PD, etc.)
  • High level of creativity and productivity with strong synthetic chemistry problem solving skills
  • Demonstrated excellence in organic synthesis and medicinal chemistry, conversant with the current literature
  • In-depth knowledge and hands-on experience with a wide range of techniques in synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.)
  • Good track record of publications and patents
  • Hands on experience using the concepts and tools of structure-based drug design
  • Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team and maintain effective working relationships
  • Effective oral and scientific/technical writing communication skills
  • Demonstrated proficiency using MS Office applications is required

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for health care and/or dependent care.

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Associate/Sr. Associate, Regulatory Affairs

Job #: 02-277

Job Title: Associate/Sr. Associate, Regulatory Affairs

Location: Waltham, MA

Company Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
This position will report to the Sr. Manager, Regulatory Affairs and be located in the Waltham, MA office.

Key Responsibilities:
• Under supervision, the Regulatory Affairs Associate will work with cross functional colleagues in providing support for clinical and CMC regulatory filings, creation of internal regulatory documents, and assist with ensuring internal compliance with GXP regulations and policies
• Define contributions for submissions, communicate to functional contributors and track delivery according to agreed timelines
• Identify and compile all materials required in U.S., EU, and other ex-US regulatory submissions, this includes annual reports, DSURs for INDs, CTAs, IND/NDA/MAA applications, etc. as necessary
• Review regulatory submissions to ensure that the elements, quality, accuracy, and format are consistent and comply with applicable laws, regulations and corporate standards
• Responsible for project managing and producing submissions in collaboration with Regulatory Affairs and other team members
• Coordinates with the submissions vendor, ensuring industry and company-defined standards are met
• Proficient in MS Office Applications including MS Outlook, MS Word, MS Excel, MS Powerpoint, and MS Project

Required Qualifications:
• The Regulatory Affairs Associate is ideal for candidates with a BA/BS degree or higher and 1-3 years of full-time (not degree related) experience in clinical research, regulatory affairs, or a related field regulated by the FDA
• Proficiency in regulatory (FDA, ICH, GCP, and GMP) guidelines
• Experience with Veeva EDMS is preferable
• Keen planning skills but must also possess the skills to work in a high-paced work environment and be able to effectively manage multiple tasks
• Should be able to present their ideas clearly and concisely and have excellent written and oral communication skills
• Highly detail-oriented and organized

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Associate Director/ Sr. Manager, Chemical Engineering, MS&T

Job #: 02-276

Job Title: Associate Director/ Sr. Manager, Chemical Engineering, MS&T

Location: Waltham, MA

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking a Chemical Engineer experienced in small molecule process development and manufacturing to join our MS&T team to support drug substance development activities. The ideal candidate will have a BS, or MS, in Chemical Engineering, or related field with experience in developing GMP drug substance manufacturing in a virtual environment. The candidate should also have a command of chemical synthesis and purification for small molecule drug substance (active pharmaceutical ingredient) and intermediate unit operations. Specific areas with which the candidate should be familiar include, but are not limited to crystallization engineering, batch processes, reaction scale-up, and particle-sizing technologies. The candidate should have hands-on experience with development and implementation of controls and processes needed to manufacture under GMP requirements. Familiarity with regulatory writing, quality management and oversight of CMO activities, and review of batch records and technical reports and qualifications are also important. The successful candidate will be strong in both written and spoken communications, well-organized, and able to thrive in a fast-paced environment.

Key Responsibilities:
• Design and manage virtual process development activities, as well as provide oversight to contract manufacturers of drug substance, across a diverse range of unit operations partners to support development, qualification, supply, and cGMP manufacture.
• Provide technical review of supplier batch records for development/tech transfer and related GMP documentation (e.g., raw material and product specifications, equipment specifications, validation protocols/reports).
• Maintain CQA, in-process, and release data tracking and trending analysis.
• Maintain in-process equipment parameter tracking and trending analyses.
• Assist in providing ‘person in plant’ oversight to GMP related activities.
• Assist in execution of formalized process risk assessment activities (e.g. FMEA) to support process qualification and regulatory submissions.
• Help oversee CMO development and qualification activities required to support and launch activities as well as advise on additional early phase program development.
• Support writing and review applicable sections of CMC regulatory filings.
• Author and review relevant MS&T SOP’s in collaboration with QA

Required Qualifications:
• Bachelor’s Master’s (Preferred) with at least 7 years of experience in small molecule pharmaceutical process development.
• Strong understanding of design and development of small molecule drug substance manufacturing processes from development studies through commercialization.
• Chemical synthesis and purification unit operations to support scale-up and manufacturing at various production scales.
• Current in cGMPs and how to implement processes which are compliant.
• Proficient in MS Excel, MS Word, SciFinder, MS Project, ChemDraw. Knowledge of JMP or other statistical analysis software as well as reaction modeling software (e.g. Visi-mix, Dynochem) and stability-predicting software (e.g. Slimstat, iStability) preferred.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Director/Senior Director, Regulatory Affairs

Job #: 02-275

Job Title:  Director/Senior Director, Regulatory Affairs

Location: Waltham, MA

Role Summary:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

  • providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
  • a diverse and multi-disciplinary workforce
  • dedicated and talented people who are passionate about achieving excellence in all they do
  • a work environment that allows you to balance your priorities
  • above all else, a commitment to the patients we serve

Position Summary:

The Director/Senior Director, Regulatory Affairs will manage a group of highly motivated, top-notch regulatory professionals and will be a key player in shaping cohesive regulatory strategies across the development pipeline. 

This position will report to the Vice President of Regulatory Affairs and Quality and be located in the Waltham, MA office.

Key Responsibilities:

  • Working with the regulatory leads to develop regulatory strategies for multiple oncology development programs (from FIH through post-marketing stage)
  • Address complex issues by providing solid regulatory solutions and guidance to the regulatory leads and, as needed, to the cross-functional teams and senior management
  • Monitor global regulatory changes that may impact asset development
  • Provide tactical support and operational expertise when “hands on” support is needed
  • Counsel and advise Vice President of Regulatory Affairs & Quality on the status of Regulatory Affairs strategies and tactics, procedures and practices
  • Ensure compliance of regulatory strategies and submissions
  • Assess project plans and timelines; manage staff effectively to ensure all projects are appropriately prioritized and key goals are met on time
  • Contribute to the continuous improvement of existing department processes and create new processes to support the evolution of the company
  • Manage staff performance and plays a key role in developing career growth opportunities for staff

Required Qualifications:

  • Ph.D. and 10+ years of work experience in pharmaceutical regulatory affairs, or • B.S/M.S. and 12+ years of work experience in pharmaceutical regulatory affairs
  • Advanced knowledge and experience in interpretation of regulations, guidelines and precedents related to oncology drug development in the US and EU
  • Must have experience filing INDs and NDAs/BLAs

Preferred Qualifications:

  • Capable of strategic thinking and proposing innovative solutions to regulatory problems
  • Demonstrates excellent verbal and written communication skills with ability to positively impact and influence peers, direct reports, and supervisor

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Senior Human Resources Business Partner, Commercial

Job #: 03-239

Job Title: Senior Human Resources Business Partner, Commercial

Location: Waltham, MA

Company Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
Deciphera Pharmaceuticals, a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, is seeking a Human Resources Business Partner to support its growing Commercial Organization. The ideal candidate will be a proactive, strategic partner to the Commercial Organization, and will be experienced in handling a variety of HR tasks, particularly supporting the strategic HR needs of a rapidly growing commercial team.

It’s an exciting time at Deciphera! The company is growing as it accelerates from its clinical stage to a fully-integrated, commercial-stage company. Ripretinib or DCC 2618, the lead asset in Deciphera’s wholly-owned, robust oncology pipeline, is in Phase III pivotal trial in its lead indication, GIST. Ripretinib is a broad-spectrum KIT and PDGFRa kinase switch control inhibitor, and it is currently in development for the treatment of systemic mastocytosis and other solid tumors as well. The Human Resources Business Partner position will be instrumental in supporting the Commercial organization, particularly as it continues through its high growth phase.

This position will report to the Vice President of Human Resources in the Waltham, MA office.

Key Responsibilities:
Strategic HR Consultation, Talent Management, and Organizational Effectiveness
• Takes a proactive approach to partner with business groups to anticipate, assess, and provide HR solutions in relation to business needs, with guidance as needed from the VP of HR
• Provides timely and effective advice on HR-related matters to employees and managers
• Implements various aspects of the HR/Business priorities set by the leadership team
• Contributes to the development of the commercial Work Force Plan, ensuring that hiring planning meets the needs of the growing business.
• Supports efforts around increasing employee and manager engagement
• Coaches functional management to increase people manager acumen and accountability
• Acts as an employee champion and identifies trends to help inform/support management to build an effective culture at Deciphera
• Contributes to the design of, and delivers, HR-related communications
• Proactively ensures an understanding of the messages and adherence to changes
• Supports the development and implementation of talent management initiatives and programs, including performance management, competency modeling, employee development, management development, and career development/succession planning
• Prepares ROI justification for training initiatives and articulates the value to management
• Provides performance management advice and counsel to employees and managers

Other Responsibilities include:
Employee Relations
• Serves as consultant to employees and managers on a variety of issues such as training needs, performance management, policy interpretations, career development, and other issues impacting productivity or morale
• Identifies opportunities to reduce employee relation issues overall
• Conducts thorough and confidential investigations in response to formal complaints

Performance Management
• Provides input into the development, implementation, and administration of HR policies and procedures and their dissemination through various employee communications
• Work with HR Operations to advise managers and employees on a wide array of benefits and compensation-related matters; partner with leadership and HR Operations to build effective sales incentives.

On and off-boarding in conjunction with the Talent Acquisition and HR Operations teams
• Provide input on and partner with line managers to facilitate functional onboarding for new employees
• Create best practice process, reference material, tools for team to share workflows
• In partnership with HR Operations and Talent Acquisition, identify areas of process improvement and make recommendations to scale and simplify – work with centers of excellence

Requirements:
• Bachelor’s Degree; Advanced Degree in Human Resources, Organizational Development, or Industrial Relations, or MBA preferred.
• 5+ years of HR experience; 3+ years Human Resources Business Partner experience. Experience supporting commercial organizations in the BioPharmaceutical industry a plus
• Strong MS Outlook, Word, Excel and PowerPoint skills
• High level of integrity and trustworthy
• Excellent communication and influencing skills with a demonstrated ability to build relationships with senior and executive leaders.
• Strong knowledge of organizational development, employment law, employee relations, diversity & inclusion, performance management, and federal and state employment laws


Preferred Qualifications:
• The ability to interact with staff (at all levels) in a fast-paced environment, sometimes under pressure, remaining flexible, proactive, resourceful and efficient, with a high level of professionalism and confidentiality is crucial to this role.
• Self-motivated, assertive, and self-confident with a strong business acumen and the ability to act with urgency and passion.
• Proven ability to work with a high level of integrity, accuracy, and attention to detail.
• Strong organizational skills in order to maintain a high level of productivity, innovation, and priority-setting in order to complete assignments on-time and on-budget.
• Ability to effectively read and interpret information, present numerical data in a resourceful manner, and skillfully gather and analyze information
• Ability to make thoughtful, integrated, timely and meaningful decisions and take corresponding actions.
• Resourceful, creative, enthusiastic, and results-oriented.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Associate Director, Regulatory Systems and Information Management

Job #: 03-238

Job Title:  Associate Director, Regulatory Systems and Information Management

Location: Waltham, MA

Role Summary:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients by tackling key mechanisms of drug resistance that limit the rate and/or durability of response to existing cancer therapies. Our small molecule drug candidates are directed against an important family of enzymes called kinases, known to be directly involved in the growth and spread of many cancers. We use our deep understanding of kinase biology together with a proprietary chemistry library to purposefully design compounds that maintain kinases in a “switched off’ or inactivated conformation. These therapies comprise tumor-targeted agents designed to address therapeutic resistance causing mutations and immuno-targeted agents designed to control the activation of immunokinases that suppress critical immune system regulators, such as macrophages. We have used our platform to develop a diverse pipeline of tumor-targeted and immuno-targeted drug candidates designed to improve outcomes for patients with cancer by improving the quality, rate and/or durability of their response to treatment.

We are seeking an Associate Director, Regulatory Systems and Information Management to provide technical and hands-on leadership. A successful Associate Director would be a fast learner that can understand the company’s operations to provide support and expand services. We are looking for a hands-on associate director that can assist in various projects as well as providing technical feedback for the team members.

This position will be based in Waltham, MA and report to the Director, Information Technology.

Key Responsibilities:

  • Primary ownership of Regulatory Systems for Deciphera IT
  • Primary system administrator in the company for planned application development and system implementation, administration, migration and training of a Veeva Vault Information Management solution for current and new employees and contractors.
  • Monitor alerts and troubleshoot critical production issues impacting end-users, including system unavailability and data integrity issues.
  • Provide training and mentoring with multiple departments into the use and abilities of Information Management solutions.
  • Work with project team members in the selection, development, testing, validation, training, implementation and ongoing support of business systems.
  • Participate in User Acceptance Testing, as well as oversee and participate, as needed, in Installation Qualification (IQ), Operational Qualification (OQ) and Performance Qualification (PQ). IQ/OQ/PQ .
  • Implements policy directives and instructions to manage information through its life cycle regardless of media.
  • Primary contact and administrator for multiple platforms and vendors to ensure quality of deliverables.
  • Provide support to developers during regular code releases.
  • Assist with the development and implementation of SOPs, training materials, system job aids, work instructions and help guides.

Required Qualifications:

  • Bachelor’s degree in Computer Science or related field.
  • 5+ years IT experience in the life sciences industry
  • Veeva Vault Certified Administrator with a minimum of 2 years’ experience configuring Veeva Vault and an excellent understanding of all available Veeva modules.
  • Strong software proficiency with Microsoft Office, Starting Point and other desktop applications on both Mac and PC (Windows 10) operating systems.
  • Evaluate new technologies that relate to the IT strategy.
  • Experience implementing new Enterprise Systems.

Preferred Qualifications:

  • Experience with PleaseReview administration.
  • Knowledge of database management system (DBMS) solutions to create, retrieve, update and manage data.
  • Provide training and educational opportunities for new IT services and trends to employees.
  • Pharmaceutical or scientific knowledge to help evaluate and expand clinical services.
  • Strong organizational skills to help maintain current IT projects and progress.
  • Excellent verbal and written communication skills.
  • Strong interpersonal skills to establish a good working relationship with colleagues, while maintaining professional standards.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Manager/Senior Manager, Pharmacovigilance Scientist

Job #: 02-274

Job Title:  Manager/Senior Manager, Pharmacovigilance Scientist

Location: Waltham, MA

Role Summary:

At Deciphera Pharmaceuticals, we are developing novel drug candidates to improve the lives of cancer patients by addressing key mechanisms of tumor and drug resistance that limit the effectiveness of many cancer therapies. Our pipeline of drug candidates is designed to stop cancers from growing and spreading by inhibiting mutant forms or over expression of a family of enzymes called kinases.

Enabled by our proprietary kinase switch control inhibitor platform, we have built a diverse pipeline of wholly-owned, orally administered drug candidates that includes three clinical-stage and two research-stage programs. We designed our lead drug candidate, ripretinib (DCC-2618), to inhibit the full spectrum of the known mutant KIT and PDGFRα kinases that drive cancers such as gastrointestinal stromal tumors (GIST), and to also inhibit amplified or mutant forms of these kinases that are involved in certain solid tumors, gliomas and advanced systemic mastocytosis (ASM).

We are also developing two other clinical-stage drug candidates, DCC-3014 and rebastinib, as immuno-oncology kinase, or immunokinase, inhibitors targeting the kinases CSF1R, and TIE2 kinase, respectively.

Key Responsibilities:

  • This Manager/Sr Manager, Pharmacovigilance Scientist will lead processes for safety signal management activities and aggregate reports. This role will respond to safety questions from stakeholders, reviewing medical and scientific literature for safety information.
  • Create and maintain an effective signal tracking process to capture signaling activities
  • Act as PV expert to Clinical Operations, Biostatistics, Regulatory Affairs and partners/vendors utilized for clinical trials
  • Prepares aggregate safety reports (e.g. DSURs, PSURs), including project management, safety database requests, understanding and writing the content, assimilating information from other groups, and quality checks
  • Oversee safety data analysis and medical coding
  • Conduct literature surveillance
  • Contribute to health authority and other safety related query responses
  • Ensure compliance with PV regulations per FDA, EMA, ICH, etc.
  • Ensure compliance with Deciphera and PVG & Risk Management policies and procedures
  • Provide leadership in the development, implementation, and maintenance of robust procedures for the planning, preparation, and submission of high-quality safety reports

Required Qualifications:

  • BS or BA in health discipline with preference for advanced clinical degree (PharmD, MPH, MSN) or extensive PV Experience.
  • 5 years industry experience, with at least 3 years of PV experience.
  • Experience will include aggregate safety reports and safety signal management in clinical trial drug safety
  • Proven ability to analyze and present scientific and medical data
  • History of collaboration and work in an effective team environment with internal and external partners and vendors
  • Experience leading projects capturing AE signals and writing aggregate data reports, and responses to regulatory agency requests.
  • Applies clinical judgment to interpret case information.
  • Strong Pharmacovigilance and drug development foundation, including knowledge of clinical trial safety regulations and post-marketing including case processing, expedited reporting rules, and safety databases
  • Basic knowledge of common software (EXCEL, PowerPoint, Microsoft Word, Business Objects)

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Executive Assistant

Job #: 03-236

Job Title:  Executive Assistant

Location: Waltham, MA

Role Summary:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients.  We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality and durability of their responses to treatment.  We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

  • Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
  • Surrounded by diverse, multi-disciplinary, dedicated and talented workforce who are passionate about achieving excellence in all they do
  • Driven by a work environment that allows employees to balance their priorities
  • And above all else, focused on doing the right thing for the patients and their caregivers

This is an exciting opportunity to become part of Deciphera as we prepare for growth, moving into a new building, and the launch of our first oncology product. If you are someone who enjoys the administrative challenges and opportunities of a growing biopharmaceutical company this is the job for you!

In this role you will support executives in multiple functions/departments.

Key Responsibilities:

  • Support executive(s) and direct reports with complex calendar management, prioritizing commitments, and travel arrangements (planning itineraries, developing agendas, meeting materials and reporting expenses).
  • Scheduling and planning, anticipating needs and proactively and effectively managing time accordingly
  • Plan and organize both internal and off-site events and meetings, including selecting venues, developing agendas, coordinating travel, meals, etc.
  • Vendor management – open POs, contracts, process invoices for payment, etc.
  • Assist with managing budgets, track and update spending
  • Work closely and effectively with the leadership team to keep them well informed of upcoming commitments and responsibilities, following up appropriately.
  • Represents executive(s) in interactions with both internal and external stakeholders on a daily basis, operating with efficiency, enthusiasm, and professionalism.
  • Maintain filing systems to ensure proper and timely handling of correspondence, documents, materials and records.

Required Qualifications:

  • 5 + years related experience working in a high-growth and fast-paced environment.
  • Experience in the biotech or pharmaceutical industry required.
  • Experience supporting senior level executives preferred.
  • Superior organizational, administrative, analytical skills and exceptional attention to detail.
  • A tenacious yet flexible problem-solver with an ability to manage complex tasks, prioritize competing demands and meet deadlines.
  • Ability to manage the activities and schedules of multiple senior leaders with little or no supervision and maintain strict confidentiality.
  • Skilled at exhibiting patience, respect and grace under pressure.
  • Critical thinker who is proactive.
  • Team player, who fosters collaboration.
  • Strong communication skills.
  • MS Office skills required (Outlook, PowerPoint, Excel).
  • Bachelor’s degree preferred.
  • This is an in-office position based at Deciphera in Waltham, MA during regular business hours, Monday through Friday.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Quality Validation Manager

Job #:02-273

Job Title: Quality Validation Manager

Location: Waltham, MA

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients by tackling key mechanisms of drug resistance that limit the rate and/or durability of response to existing cancer therapies. Our small molecule drug candidates are directed against an important family of enzymes called kinases, known to be directly involved in the growth and spread of many cancers. We use our deep understanding of kinase biology together with a proprietary chemistry library to purposefully design compounds that maintain kinases in a “switched off’ or inactivated conformation. These therapies comprise tumor-targeted agents designed to address therapeutic resistance causing mutations and immuno-targeted agents designed to control the activation of immunokinases that suppress critical immune system regulators, such as macrophages. We have used our platform to develop a diverse pipeline of tumor-targeted and immuno-targeted drug candidates designed to improve outcomes for patients with cancer by improving the quality, rate and/or durability of their response to treatment. We offer an outstanding culture focused on:
• Providing a collaborative and energized work environment
• A diverse and multi-disciplinary workforce
• Dedicated and talented people who are passionate about achieving excellence in all they do
• A commitment to the patients we serve

We are seeking a Quality Validation Manager to lead the organization as the Quality representative for all process validation activities from the Drug Substance through to Commercial Packaging. The primary function of this position will be to work directly with contract manufacturers to successfully complete the process validation of DCC-2618 (Ripretinib) and other programs.

This position will report to the Director of GMP/GDP/GLP Quality and be located in the Waltham, MA office.

Key Responsibilities:
• Overall Quality responsibility for the Deciphera process validation program and activities, including technology transfer.
• Provide Quality oversight and management of Deciphera partners to identify validation approach, strategy and execution.
• Review and approval of process validation and shipping validation plans, protocols and reports.
• Ensure all validation activities are performed in compliance with GMP regulations and are in an inspection ready state.
• Manage and approve deviations and change requests related to systems, equipment, manufacturing processes and facilities related to any potential validation activity/status.
• Develop validation processes and procedures.
• Update Sr. Management on validation activities and status.

Required Qualifications:
• Minimum Bachelor’s degree in Engineering or Science
• Minimum 5 years of direct experience in biologics/pharmaceutical validation and/or process development under CGMP regulations.
• Excellent written and verbal communication skills, including ability to communicate clearly, concisely and effectively.
• Strong knowledge of quality systems and regulatory requirements across US and EU regulatory authorities.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Senior Clinical Financial/Business Operations Analyst

Job #:02-270

Job Title: Senior Clinical Financial/Business Operations Analyst

Location: Waltham, MA
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients by tackling key mechanisms of drug resistance that limit the rate and/or durability of response to existing cancer therapies. Our small molecule drug candidates are directed against an important family of enzymes called kinases, known to be directly involved in the growth and spread of many cancers. We use our deep understanding of kinase biology together with a proprietary chemistry library to purposefully design compounds that maintain kinases in a “switched off’ or inactivated conformation. These therapies comprise tumor-targeted agents designed to address therapeutic resistance causing mutations and immuno-targeted agents designed to control the activation of immune kinases that suppress critical immune system regulators, such as macrophages. We have used our platform to develop a diverse pipeline of tumor-targeted and immuno-targeted drug candidates designed to improve outcomes for patients with cancer by improving the quality, rate and/or durability of their response to treatment.,

This position will report to the Director, Clinical Business Planning and be located in the Waltham office.

Role Summary:

We are seeking a dynamic individual to join our Clinical Operations department to contribute to the success of Deciphera, a high-growth biotech company in Waltham. This position will be an integral member of Clinical Business Operations in support of Global Clinical Site Payment Management. Key responsibilities include ensuring clinical study sites are set up properly for payments as well as overseeing the accurate and timely payments to sites. This position requires strong organizational and analytical skills, resourcefulness, and autonomy in accomplishing a wide variety of tasks. The Senior Clinical Financial/Business Operations Analyst will collaborate across the Clinical and Finance organizations and have the opportunity to help impact the lives of our patients.

Primary responsibilities:

Site Payments:

• Provide integral support for site payment vendor management
• Review the accuracy of the site payment configurations as built within the vendor payment system
• Work with Deciphera Clinical Project Managers and/or Clinical Trial Associates for study, site, and patient specific budget/payment inquiries
• Suggest modifications to budget templates and/or parameters based upon ongoing experience with clinical trial activity
• Ensure final CTA, including Schedule of Assessments and Budget Exhibits, are clear to enable payments to be made via site payment vendor
• Review for consistency in content across core documents, i.e., CTA, Budget Exhibit and Excel budget
• Review and approve site payments and other payment activities
• Qc and analytical support for actual expenses as related to site payment activity
• Work with Accounting and Finance organization as needed

Business Planning/Operations:

• Provide support in execution of the quarterly forecast and budget cycles
• Assist in preparation of forecasting meeting minutes
• Clinical Operations and/or Finance activities as needed

Activities May Include:

• Provide assistance with site financial issues as needed
• Contracts support such as assistance with implementation of a Contracts Management System
• Review and approve site budget templates for each study developed by CRO, including country specific modifications

Required Qualifications:
• 3-5 years of clinical trial experience at a clinical site, CRO, or sponsor biopharmaceutical organization
• Prior in-house experience as a member of a clinical operations department in a biotechnology or pharmaceutical company strongly preferred
• BS/BA or equivalent degree
• Strong EXCEL skills
• Strong attention to detail and highly analytical
• Demonstrated ability to multi-task, problem-solve and operate in a fast-paced environment
• Excellent verbal and written communication skills
• Flexibility to adapt to the dynamic needs of a growing biotech company

Preferred Qualifications:
• Small company experience is a plus for this is a hands-on individual contributor role.
• Prior experience working with site payment vendor(s) an incredible plus
• Clinical trial experience specific to Oncology

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for health care and/or dependent care.

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Program Manager, Medical Affairs

Job #: 02-272

Job Title: Program Manager, Medical Affairs

Location: Waltham, MA

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients by tackling key mechanisms of drug resistance that limit the rate and/or durability of response to existing cancer therapies. Our small molecule drug candidates are directed against an important family of enzymes called kinases, known to be directly involved in the growth and spread of many cancers. We use our deep understanding of kinase biology together with a proprietary chemistry library to purposefully design compounds that maintain kinases in a “switched off’ or inactivated conformation. These therapies comprise tumor-targeted agents designed to address therapeutic resistance causing mutations and immuno-targeted agents designed to control the activation of immunokinases that suppress critical immune system regulators, such as macrophages. We have used our platform to develop a diverse pipeline of tumor-targeted and immuno-targeted drug candidates designed to improve outcomes for patients with cancer by improving the quality, rate and/or durability of their response to treatment.

Role Summary:

Deciphera Pharmaceuticals is searching for a highly motivated, insightful, and resourceful individual to join its newly formed Medical Affairs team.

Reporting directly to the Vice President, Medical Affairs, this highly visible Program Manager role will have the rare opportunity to build the Medical Affairs Program Management function from the ground up as Deciphera prepares to launch its first commercial therapy, Ripretinib.

The Program Manager provides operational support to cross-functional Medical Affairs team and oversees the planning and tactical execution of medical plans and projects within the Medical Affairs department including launch plans. This position steers the development and tracking of high quality, integrated cross-functional medical plans and tactics, and includes interacting with multiple functions within Medical Affairs (including Operational Excellence Director, Medical Science Liaisons, Medical Directors, Medical Information, Medical Communications) as well as others in the Health Economics and Outcomes Research, Clinical Development, Real-World Evidence, Commercial, and Regulatory departments.

The successful candidate is expected to apply project/program management best practices in the development, planning, execution, maintenance, and closing of projects. The Program Manager will also identify risks, timeline delays and other issues. The ideal candidate will be a team player with well-developed collaboration skills who will ensure effective communication among team members.

Key Responsibilities:

  • Lead the development of high-quality medical plans, including product launch plans, and ensure alignment between overall program strategy and cross-functional plans.
  • Provides project updates to Medical Affairs team for incorporation into strategic deliverables and program timelines.
  • Communicates program status through monthly dashboards and other reporting materials and proactively identify issues/delays. This includes collecting information and ensuring accuracy of reports.
  • Provide meeting management and facilitation support to the Medical Affairs team to ensure projects and plans move forward.
  • Regularly meet with stakeholders for project updates.
  • Monitor program budget/spending.
  • Apply project management best practices and processes.
  • Develop and track medical plan projects, assist with risk mitigation planning, identify project contingencies.
  • Escalates project issues and risk mitigations to Medical Affairs team in a timely manner.
  • Assist Medical Affairs with development of Governance Board deliverables as needed.
  • Supports department initiatives, as needed.

Required Qualifications:

  • Bachelor’s degree required.
  • 3-5 years’ experience in a Medical Affairs Project Management role in the biopharmaceutical industry with Product Launch experience preferred.
  • Drug Development knowledge with basic to strong understanding of other functions relevant to the position including Research, Pre-Clinical, Clinical, Commercial, and Regulatory.
  • Proficiency in Project Management best practices and tools including MS Project.
  • Strong interpersonal skills with experience leading cross-functional teams in matrix environment preferred.
  • Demonstrated managerial courage to make and stand by difficult decisions.
  • Strong ability to communicate complex issues in a simple way and to orchestrate plans to resolve issues and mitigate risks.
  • Demonstrated ability to work independently, manage competing demands and adjust approaches/methods to best fit the situation with maturity and professionalism, and follow tasks through to completion.
  • Thrive working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful and efficient. Able to deal with ambiguity and to act without having the complete picture.
  • Quick learner, goal oriented, and results-driven with excellent technical and problem-solving skills, and the ability to escalate issues appropriately.
  • Strong business acumen and critical thinking.
  • Good verbal and written communication skills.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Intern (Analytical Chemistry)

Job #:04-213

Job Title: Intern (Analytical Chemistry)

Location: Lawrence, KS

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:
• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

We are seeking an Intern to work within our drug discovery team to assist in the development of the company pipeline of drugs to treat human diseases. This position will report directly to a Senior Scientist in Chemistry and be located in the Lawrence, KS research facility.

Key Responsibilities:
• Weighing compounds for assay by Deciphera’s QA/QC department for acceptance into the company’s screening library. Accurately record the obtained weights and document as required and enter the correct information for individual sample vials. Print labels and apply to the appropriate vial.
• Assist in weighing and packaging of compounds for outsourcing to collaborating laboratories.
• Assist in the upkeep of the Deciphera’s compound inventory.
• Understand and follow all of the companies pertinent safety requirements, including the wearing of gloves and safety glassing while in the laboratory.

Required Qualifications:
• Must be able to transfer milligram amounts of stock sample and accurately weigh using an analytical balance.
• Able to understand and follow Deciphera’s internal standard operating procedures.
• Willingness to take instruction and be able to provide a very high level of attention to detail in all aspects of the assigned tasks.
• A working knowledge of Excel, or similar data processing software, is a definite plus.
• Good knowledge and/ or experience in analytical chemistry (or a similar laboratory / engineering discipline) is a plus.
• Willingness to seek input from others on ideas and problem-solving and use others as a resource.
• An interest in gaining experience in scientific /laboratory environments is a plus.
• Willingness to work in dynamic environment and contribute to a continued enjoyable work atmosphere.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Associate Director, Pharmacovigilance

Job #:02-271

Job Title:  Associate Director, Pharmacovigilance

Location: Waltham, MA

Role Summary:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients by tackling key mechanisms of drug resistance that limit the rate and/or durability of response to existing cancer therapies. Our small molecule drug candidates are directed against an important family of enzymes called kinases, known to be directly involved in the growth and spread of many cancers. We use our deep understanding of kinase biology together with a proprietary chemistry library to purposefully design compounds that maintain kinases in a “switched off’ or inactivated conformation. These therapies comprise tumor-targeted agents designed to address therapeutic resistance causing mutations and immuno-targeted agents designed to control the activation of immunokinases that suppress critical immune system regulators, such as macrophages. We have used our platform to develop a diverse pipeline of tumor-targeted and immuno-targeted drug candidates designed to improve outcomes for patients with cancer by improving the quality, rate and/or durability of their response to treatment.

The Associate Director, Pharmacovigilance will manage pharmacovigilance activities. Works with partners and external service providers to ensure that safety data is processed according to internal conventions and international regulations and guidelines. Assists with planning and implementation of safety system enhancements and upgrades. Develops and maintains the necessary processes to ensure high quality safety database outputs. Serves as pharmacovigilance expert in cross-functional meetings including externally conducted research. Surveillance activities providing scientific/clinical PV expertise with a focus on the identification, evaluation and management of safety risks. The position is expected to contribute to aggregate safety documents, including but not limited to the IB, DSURs, and ad hoc analyses. This role reports to the Head of Safety.

This position will report to the Senior Director, Pharmacovigilance and be located in the Waltham office.

Key Responsibilities:

  • Provides oversight and review of vendor case processing and submission activities by external vendor, including the review and monitoring of compliance through various monitoring reports and other oversight activities.
  • Establishes CRO and vendor oversight procedures and Key Performance Indicators (KPIs). Generates metrics and provides feedback.
  • Supports the oversight and management of global business partner safety data exchange agreements/ pharmacovigilance agreements and other contracts as applicable to ensure compliance with data exchange activity. Communicates with partner companies and vendors regarding processing and timely exchange of safety data. Distributes aggregate reports as required and assists with reconciliation activities.
  • Develops and maintains Medical Safety and Pharmacovigilance related documents including Safety Management Plans, SOPs and Work Instructions, and Safety Data Exchange Agreements.
  • Works cross functionally with Regulatory Affairs and Quality Assurance functions to maintain current knowledge of regulatory safety reporting guidelines and implementing relevant guidelines into Intercept practices and procedures.
  • Participates in internal audits and global regulatory inspections as a SME for specific PV topics and processes.
  • Adheres to company policies and applicable regulations including reporting of adverse events to regulatory agencies
  • Interfaces with other departments (e.g. clinical development, clinical operations, regulatory affairs, data management, biostatistics) regarding safety data collection, analysis, and reporting.
  • Provides direct technical /data management support to ensure information entered and retrieved from the safety database is consistent, accurate and complete in accordance to data requests. Performing and contributing to safety monitoring and signal detection activities for products including signal identification, evaluation, interpretation of safety signals and prioritizing signals for full evaluation and communication of safety risks. Perform ad hoc analyses as required
  • Other responsibilities as assigned.

Required Qualifications:

  • Bachelors/Advanced degree preferably in life science, nursing, pharmacy or other healthcare related profession (MD, RN, PharmD, NP, PhD, MPH, etc.)
  • 5 – 7 years of direct pharmacovigilance work experience in the pharmaceutical industry
  • Experience with Argus Safety database is a must
  • Knowledge of GCPs, ICH guidelines and FDA, EMA, and other international regulations and guidelines
  • Knowledge of MedDRA and WHO Drug dictionaries
  • Experience with overseeing and managing vendors
  • ICSR submission experience is highly preferred
  • Strong interpersonal and communication skills; proactive approach. Able to work both independently and in a team environment.
  • Detail-oriented, with good organizational, prioritization, and time management proficiencies. Must be able to work on multiple projects simultaneously
  • Demonstrated problem solving skills (including taking ownership to ensure timely resolution), a strong sense of urgency, keen attention to detail, and the ability to successfully execute in an environment under time and resource pressures
  • Proficient in standard computer software (Word, Excel and Power point presentations)
  • Previous experience and formal training with safety database programs including configuration and validation activities is desired

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.


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Recruiting Coordinator

Location: Waltham, MA

Job #::03-234


This is an exciting opportunity to join Deciphera Pharmaceuticals in a Recruiting Coordinator role.

Deciphera is a growing, well-funded clinical stage company.  Over the past year we have doubled in size and plan to continue to grow as our lead oncology program moves into phase 3 clinical development.

As part of the Human Resources team you will have the opportunity to collaborate with people from all departments and functions.  In this highly visible role, you will support candidates and hiring managers through all stages of recruiting and on-boarding.

Deciphera offers an outstanding culture focused on these key principles:

  • Providing a collaborative and energized work environment
  • A diverse and multi-disciplinary workforce
  • Dedicated and talented people who are passionate about achieving excellence in all they do
  • A commitment to the patients we serve

If this motivates you and sounds like you, we want to hear from you!

Specific responsibilities include:

  • Coordinate and schedule candidate interviews
  • Manage job postings and applicant tracking system
  • Candidate offer letters
  • Greet and provide general support to guests and candidates
  • Support Talent Acquisition team
  • Partner with the HR team on employee communications, employer branding/social media, employee referral and other promotional programs

Qualifications:

  • Bachelor’s degree with relevant office work experience
  • Energetic, can do attitude
  • Team player a must
  • Great communication and writing skills
  • Excellent customer service skills and attention to detail
  • Strong MS office skills including – Outlook, PowerPoint and Excel
  • Experience with Applicant Tracking Systems a plus, but not required
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Senior IT Support Analyst

Job #: 03-233

Location:  Lawrence, KS

Role Summary:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients by tackling key mechanisms of drug resistance that limit the rate and/or durability of response to existing cancer therapies. Our small molecule drug candidates are directed against an important family of enzymes called kinases, known to be directly involved in the growth and spread of many cancers. We use our deep understanding of kinase biology together with a proprietary chemistry library to purposefully design compounds that maintain kinases in a “switched off’ or inactivated conformation. These therapies comprise tumor-targeted agents designed to address therapeutic resistance causing mutations and immuno-targeted agents designed to control the activation of immunokinases that suppress critical immune system regulators, such as macrophages. We have used our platform to develop a diverse pipeline of tumor-targeted and immuno-targeted drug candidates designed to improve outcomes for patients with cancer by improving the quality, rate and/or durability of their response to treatment.,

We are seeking a Senior IT Support Analyst to be responsible for providing the Deciphera community with a highly productive workspace environment along with solid mobility capabilities including a satisfactory 24×7 end-to end support model.

This position will report to the Director, IT and be located in the Lawrence, KS office. 

Key Responsibilities:

  • Performs on-site tier2 support – resolution of PC, iPad and smartphone requests including diagnosis, problem resolution, escalation and follow-up with Associates on specific requests.
  • Monitors administrative activities including project updates and status reports, as necessary.
  • Infrastructure administrative and support, as necessary.
  • Actively participates in Engineering projects, for example maintaining our image, testing new software to make sure that it is compatible with current image, acts as a resource for other department for testing programs and systems to increase operational efficiency.
  • Develop and continually improve a Knowledge Base for improved incident resolution and user self-service.
  • Creates and maintains documentation for systems and solutions as they are installed and upgraded.  Publishes the documentation to shared repositories and updates repository, as needed.
  • Assist with network operational issues including but not limited to account and security administrations.
  • Other duties as assigned

Required Qualifications:

  • Proven ability to work with a high level of integrity, accuracy, and attention to detail.
  • Strong technical/analytical skills to identify and solve problems.
  • Self-motivated, confident with the ability to act with urgency and passion.
  • Strong organizational skills in order to maintain a high level of productivity, innovation, and priority-setting in order to complete assignments on-time and on-budget.
  • Excellent oral and written communication skills for effectively interfacing with all levels of management and departments within the company.
  • Ability to make thoughtful, integrated, timely and meaningful decisions and take corresponding actions.
  • Willingness to work collaboratively by incorporating diverse perspectives and appropriately managing relationships in order to strengthen decision-making.
  • Proactively seeks out and recommends process improvements.
  • Entrepreneurial, enjoys working in a fast-paced, small-company environment.
  • Flexibility in handling work flow in a fast-paced environment.
  • Ability to work under pressure, meeting time sensitive deadlines, while maintaining a high level of confidentiality.

Preferred Qualifications:

  • Bachelor’s degree preferred.
  •  3 – 6 years’ experience in Help Desk Services.
  • Experience with Active Directory administration, deployments, and automation.
  • Experience supporting remote employees or virtual organizations.
  • Support of applications such as Microsoft Office with Outlook/Exchange.
  • Experience supporting iOS and Android smartphone using MDM software (e.g. Airwatch or Intune).
  • Experience supporting iPads preferred.
  • Experience supporting AV systems for conference room preferred.
  • Experience with cloud technologies such as Microsoft Azure, AWS or Office365 preferred.
  • In-depth experience of operations and control procedures.
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Sr. Total Rewards Coordinator

Job #:03-232

Job Title: Sr. Total Rewards Coordinator

Location: Waltham, MA

We are seeking a Sr. Total Rewards Coordinator to provide administrative support to the HR Operations team in the areas of onboarding/offboarding, benefits, compensation and HRIS.  

This position will report to the Manager, Total Rewards and will be located in the Waltham, MA office.

Key Responsibilities:

  • Assist in the new hire onboarding process, including day-one orientation program
  • Process new hire paperwork and related HRIS updates
  • Manage and update employee personnel files
  • Assist with benefit and compensation administration including audits, monthly invoice reconciliations, Open Enrollment support and employee requests
  • Update company org charts
  • Administer company-wide employee recognition program
  • Support day-to-day HRIS administration such as daily HRIS data entry and end-user support
  • Assist the team with ad-hoc projects

Required Qualifications:

  • Bachelor’s degree
  • 2-3 years’ experience in a corporate environment
  • Exceptional attention to detail
  • Proven excellent customer service skills and ability to be flexible, a team player
  • Demonstrated outstanding organizational skills required; ability to effectively manage multiple priorities and adapt to changing priorities
  • Excellent verbal and written communication skills coupled with a “can do” and “whatever it takes” attitude

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Associate Director/Sr. Manager, Clinical Supply Operations

Job #: :02-267

Job Title: Associate Director/Sr. Manager, Clinical Supply Operations

Location: Waltham, MA

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking an Associate Director/Sr. Manager of Clinical Supply Operations to manage day to day clinical supply activities and logistics within the Clinical Operations Group as further described below. This position will design, develop, and implement the clinical supplies strategy to ensure appropriate processes are established, and in order to achieve clinical supplies for key deliverables for each study within the program. This position will also manage supply chain activities for Phase I through commercialization and assist in the development and implementation of Investigational Supply Operations processes and procedures.

This position will report to the VP of Clinical Operations and be located in the Waltham, MA office.

Key Responsibilities:
• Plans, establishes, manages and monitors forecast activities related to drug product, and clinical supplies for multiple programs and study level, based on clinical study protocol and clinical development plans.
• Responsible for all levels of studies, ranging from simple and complex, requiring in-depth understanding of GMPs, project management, IXRS, medication management and/or use of advanced simulation tools.
• Independently responsible for development, and implementation of clinical supply plans, based on clinical development plans.
• Responsible for scheduling and delivery of CTM including strategies for creating label and packaging design, randomization, packaging, labelling and distribution of clinical supplies.
• Manages external consultants and third party vendors, including collaboration with QA on vendor selection and quality and supplier agreement development, to ensure timely and quality delivery of CTM that meets study protocol, regulatory, and budgetary requirements.
• Ensures that key project milestones are met, negotiates and communicates supply plan timelines to internal and external customers and partners.
• Develops and manages the forecasting and ordering investigational product, commercial and comparator material in global trials and share best practices with global/local sourcing teams as appropriate.
• Independently creates clinical supply study budgets.
• Monitors spend to-date compared to the approved study budget.
• Accountable and responsible for amending budgets through defined change management processes.
• Manages all finance activities with clinical team and clinical finance including request for proposal for bidding and vendor selection, purchase orders and invoice approval.
• Ensures uninterrupted supplies throughout the duration of a clinical study program.
• Maintains/tracks inventory of available clinical supplies and tracks expiration dates.
• Coordinates with CMC, in-licensing and QA partners to manage technical and quality issues to facilitate uninterrupted supplies.
• Proactively drives cross-functional activities.
• Works with other line functions and external partners to manage complex projects.
• Identifies potential system/technology improvements/enhancements.
• Maintains and ensures compliance to all SOPs.
• Identifies gaps and makes appropriate mitigation recommendations to ensure global compliance.
• Develops new functional SOPs, Policies/Plans as necessary.

• Provides training to staff.

Required Qualifications:
• 7 + years’ experience in the biopharmaceutical industry supporting complex global trials
• Ability to effectively prioritize and manage multiple projects and tasks.
• Possess a flexible approach to problem solving and strong negotiations skills.
• A team player, who listens effectively and invites response and discussion.

• A collaborator who communicates in an open, clear, complete, timely and consistent manner.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Associate Director/Director, Drug Product Manufacturing Science & Technology (MS&T)

Job #::02-268

Job Title: Associate Director/Director, Drug Product Manufacturing Science & Technology (MS&T)

Location: Waltham, MA

Role Summary:

Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

We are seeking an Associate Director/Director, Drug Product Manufacturing Science and Technology (MS&T), who will have responsibility for leading and managing late-stage development, validation and commercial manufacturing activities for drug product and packaging. The scope of the role encompasses late stage process development, scale-up, Process Performance Qualification (PPQ), routine commercial manufacturing, technical transfer and Continued Process Verification. Operating within a virtual (100% outsourced) business model, the incumbent will have accountability for CDMO oversight, and the development of strong and enduring business partnerships. The successful candidate will also assume a key role in the development, review and approval of Module 3 sections of CTD regulatory submissions, pre-approval inspections (PAIs) and written responses to regulatory authorities.

The successful candidate will have significant experience in CMC development and commercialization of small molecules and an in-depth understanding of critical-path activities and interdisciplinary connections associated with validation and commercial launch. S/he will possess strong leadership, management and communication skills, ensuring that external business partners understand and respect program goals, objectives, priorities, and timelines.

This position will report to the Sr. Director, MS&T and be located in the Waltham, MA office.

Key Responsibilities:

• Lead and manage cross-functional teams engaged in external cGMP manufacturing of bulk drug product and finished goods.
• Lead and manage process transfers, associated site implementation and PPQ to support supply chain expansion activities and post-approval continuous improvement initiatives.
• Monitor, track and trend process performance. Develop and implement data analytics to support investigations and provide historical baseline for future operational and process-related improvements.
• Support investigations, root cause identification and CAPA implementation associated with manufacturing deviations and associated quality events.
• Work closely with internal Quality Assurance, Regulatory CMC, Supply Chain and Commercial functions and external manufacturing operations to ensure operational excellence with respect to timelines, budgets, and attainment of technical, regulatory and business goals/milestones.
• Play a key role in the selection of drug product CDMOs based upon core capabilities, capacity and track record of regulatory compliance; establish KPIs to monitor site technical, quality and business performance.
• Develop and maintain strong relationships with CDMO business partners.
• Review/approve technical reports, controlled GMP documents and CMC content for Module 3 CTDs.
• Potentially represent the Technical Operations organization in meetings with FDA, EMA and related regulatory authorities.

Required Qualifications:
• A B.S./M.S. degree in chemical engineering, pharmaceutics, chemistry, or related life sciences discipline with at least 10 years of hands-on experience in small-molecule pharmaceutical product development and commercialization.
• Track record of success in leading and managing small-molecule drug product MS&T program through validation in a 100% outsourced environment.
• Thorough knowledge of current global regulatory expectations and industry best practice for Process Performance Qualification , Continued Process Verifications and implementation of Quality by design (QbD) principles.
• Strong vendor/supplier management skills and excellent communication and cross-functional collaboration skills.
• Competency in developing, implementing and delivering CMC project plans (milestones, timelines, resources, etc.) to successful endpoints.
• Ability to articulate complex issues and ideas with clarity to enable understanding and decision making.
• Ability to work successfully in a team/matrix environment and independently, as required.
• Ability to influence cross-functionally to enable improvements and enhance performance across CMC development, MS&T and supply chain functions.
• Pragmatic, solution-oriented thinker who possesses a “can do” and ”whatever it takes” attitude, coupled with excellent organizational and communication skills.
• Strong interpersonal skills with the ability to influence others, negotiate during situational conflict, and establish the best forward path in the face of competing points of view.
• Ability to travel (20%) to CDMO domestic and international sites.
• Fluency with standard computer software packages (MS Word, Excel, PowerPoint, and Project) and JMP (or similar statistical tools). 

Preferred Qualifications:
• Experience in developing and commercializing drugs for oncology and/or orphan diseases is strongly preferred.
• A Ph.D. degree in an engineering or life sciences discipline or M.B.A. in operations management is highly desired.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Director, Brand Insights & Forecasting

Job #::03-225

Reports to: Vice President, Commercial Insights & Operations

Location: Waltham, MA

Position Summary:
Deciphera Pharmaceuticals is searching for a highly motivated, insightful, and resourceful individual to join the newly formed Commercial Insights and Operations team.
Reporting directly to the Vice President of Commercial Insights and Operations, this highly visible role will have the rare opportunity to build the Brand Insights & Forecasting function from the ground up as we prepare to launch Deciphera’s first commercial therapy.
The Director of Brand Insights and Forecasting is a commercial insights generalist who is able to balance expert intra-personal skills with strong analytical acumen to translate research findings into actionable insights. The person in this role is accountable for identifying, executing, and presenting market/brand insights to guide strategic decisions that inform the creation of all launch materials and to optimize brand performance over time.
The successful candidate for this role must have in-depth experience with a variety of measurement and research methods, demonstrated strategic planning and project management, data evaluation, market research, customer insight generation and forecast triangulation methodologies. As a senior member of the commercial business, this role will serve as an internal consultant to the brand team and Commercial leaders in the organization to drive innovation and forward-thinking strategies centered on patients and customer-focused solutions.

Company Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality and durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:
• Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• Surrounded by diverse, multi-disciplinary, dedicated and talented workforce who are passionate about achieving excellence in all they do
• Driven by a work environment that allows employees to balance their priorities
• And above all else, focused on doing the right thing for the patients and their caregivers

Our Drug Discovery Engine – Kinase Switch Control Platform
Our proprietary drug discovery platform is based on our deep insight into the biology of kinases, which are regulated by control of their shape, or conformation. The transformation of a kinase from an inactive to an activated state is dependent upon the interaction of one region of the kinase called the activation switch with an area called the switch pocket; a mechanism of activation that is common among all kinases. While this activation mechanism is common among kinases, the molecular structure of the activation switch and the switch pocket varies. At Deciphera, we take advantage of this activation mechanism by engineering inhibitors that selectively bind the switch pocket, preventing activation of the kinase. By directly targeting the switch pocket, we can engineer novel kinase inhibitors that are highly selective but also broadly active against the target kinase, covering both wild-type and many or all known mutant or amplified forms.
We believe no other kinase inhibitors on the market or active in clinical development directly target the switch pocket region, making Deciphera the only biopharmaceutical company that is currently developing kinase inhibitors using this approach. Our kinase switch control inhibitors interact at a molecular level in a way that is distinct from other kinase inhibitors and are designed to generate higher and more durable rates of response. Using our kinase switch control inhibitor platform, we have developed a diverse pipeline of differentiated, wholly owned, orally administered drug candidates that include three clinical-stage and two research-stage programs.

Key Responsibilities:
• Create and leverage brand insights generated from tailored primary and secondary market research studies to guide brand launch strategy and ensure tactics maximize opportunities and minimize risks
o Design and manage all aspects of primary market research across patient, caregiver, physician and payer customers for Commercial, Medical Affairs and Patient Advocacy
o Develop robust cross-functional competitive intelligence function
o Make data-based recommendations by providing business analyses and analytical support to Sr. Management, particularly in areas where data is difficult to access / unreliable and where a high level of analytical skill is required
o Review/develop market research policies and procedures where needed
o Produce timely, accurate and effective reports integrating findings across studies to address key business questions
• Facilitate the forecasting process in collaboration with Commercial partners, Finance and Supply
o Develop key assumptions through cross-functional conversations backed by your in-depth understanding of the therapeutic area dynamics, key product attributes, drivers and barriers to adoption, and expected effectiveness of internal tactical plans
o Develop and maintain models that are appropriately robust to model assumption ranges and output long range Annual and monthly forecasts and a weekly launch forecast, leveraging a variety of approaches to triangulate on the plan and report on LBE
o Develop and implement statistical methodologies and criteria for utilizing various data (syndicated demand, trade, CRM, etc.) to improve the predictive value of forecast models and other analyses
• Build and facilitate key brand planning/performance management processes in partnership with the Brand lead, Field leadership, Finance and Supply chain to ensure effective and timely communication of actual and expected performance against the forecast: e.g. annual situational analysis, quarterly business reviews, forecast Budget, LBE and S&OP
• Develop and maintain excellent internal cross‐functional relationships with relevant stakeholders to ensure alignment with and appropriate support of corporate and functional goals
o Collaborate within Commercial Operations to ensure data integrity and accuracy in reporting
o Participate as a key thought leader of the business planning team by challenging assumptions and identifying key risks and opportunities
o Negotiate with teammates for appropriate allocation of internal analytic, IT, and operational resources ensure commercial launch readiness and ongoing operations
• Provide Insights and forecasting support for Business development and New Product Planning initiatives as needed
• Potential to build analytics and forecasting team as company grows and/or to support global launches
• Operate in adherence with legal, compliance, and regulatory guidelines in the pharmaceutical industry; build SOPs, guidelines and training to ensure broad understanding and compliance with such

Qualifications:
• BS/BA degree in business or related discipline. Advanced degree in a relevant field preferred
• 8+ years of experience within the pharmaceutical, biotechnology or consulting industries
• Oral oncolytic, rare disease and/or launch experience, is preferred
• 5+ years of progressive experience in commercial analytics, brand forecasting, strategic planning, market research, and/or consulting
• Must be a true team player – authentic, humble, able to build a positive team spirit and lead through the ups and downs of a launch, puts success of team above own interests and support everyone’s efforts to grow and develop
• Effectively and seamlessly work at multiple “altitudes” within the organization. Maintains a “no job is too big or too small” attitude necessary to succeed in a startup environment.
• Excellent interpersonal, oral and written communication skills, including ability to synthesize data and deliver a clear overview of commercial strategy, opportunity and risks for the Executive Team
• Demonstrated ability to adapt to changes in the work environment, manage competing demands and adjust approaches/methods to best fit the situation with maturity and professionalism
• Demonstrate managerial courage to make and stand by difficult decisions
• Hands-on experience and proven creativity and innovation in designing/customizing qualitative and quantitative research methodologies to address specific business needs
• Deep experience with commercial data (e.g. Rx, Patient Claims, Specialty pharmacy, Hub, EMR, etc.)
• Strong business acumen, critical thinking, along with technical and problem-solving skills
• Thrives in fast-paced, minimally structured environment, able to deal with ambiguity and can act without having the complete picture
• Ability to self-direct projects and work with little supervision
• Ability to manage periods of heavy domestic travel (20-40% of time based on market research needs)

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Sr. Director, Oncology Marketing/Launch Leader – Ripretinib

Job #: :03-224

Reports to: VP, Marketing

Location: Waltham, MA

Company Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality and durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:
• Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• Surrounded by diverse, multi-disciplinary, dedicated and talented workforce who are passionate about achieving excellence in all they do
• Driven by a work environment that allows employees to balance their priorities
• And above all else, focused on doing the right thing for the patients and their caregivers

Our Drug Discovery Engine – Kinase Switch Control Platform
Our proprietary drug discovery platform is based on our deep insight into the biology of kinases, which are regulated by control of their shape, or conformation. The transformation of a kinase from an inactive to an activated state is dependent upon the interaction of one region of the kinase called the activation switch with an area called the switch pocket; a mechanism of activation that is common among all kinases. While this activation mechanism is common among kinases, the molecular structure of the activation switch and the switch pocket varies. At Deciphera, we take advantage of this activation mechanism by engineering inhibitors that selectively bind the switch pocket, preventing activation of the kinase. By directly targeting the switch pocket, we can engineer novel kinase inhibitors that are highly selective but also broadly active against the target kinase, covering both wild-type and many or all known mutant or amplified forms.
We believe no other kinase inhibitors on the market or active in clinical development directly target the switch pocket region, making Deciphera the only biopharmaceutical company that is currently developing kinase inhibitors using this approach. Our kinase switch control inhibitors interact at a molecular level in a way that is distinct from other kinase inhibitors and are designed to generate higher and more durable rates of response. Using our kinase switch control inhibitor platform, we have developed a diverse pipeline of differentiated, wholly owned, orally administered drug candidates that include three clinical-stage and two research-stage programs.

Position Summary:
Deciphera is seeking a seasoned, dynamic commercial executive with extensive oncology experience to build and lead the company’s lead asset, DCC 2618 or ripretinib. Reporting to the VP of Marketing, this position will lead Deciphera’s brand strategy and execution for ripretinib, a broad-spectrum KIT and PDGFRa kinase switch control inhibitor currently in development for the treatment of GIST, systemic mastocytosis, and other solid tumors. This is a critical senior leadership role that will be instrumental in Deciphera’s evolution from the clinical stage into a fully-integrated, commercial-stage biopharma company.

Responsibilities:
• Being a product champion – be the strategic lead for ripretinib, and should be able to motivate and excite the entire commercial team (Sales, Market Access, Digital Marketing, Market Research and Analytics) and the company to help drive success of the product
• Being a launch champion –oversee a successful pre-launch and launch planning of ripretinib in GIST indication(s) working closely with cross-functional partners
• Develop comprehensive strategic brand plan for ripretinib with cross functional assistance and work with his/her team to execute on marketing strategies and tactics to support product’s P&L to ensure short term and long term success of the brand
• Plan and oversee the development of advertising and promotional materials and activities including print, online, and other personal and non-personal promotional efforts
• Develop and manage the marketing operating budget and recommend product positioning, messaging and pricing strategy to produce the highest possible long term market share and success for ripretinib
• Identify Market Research and insight needs for ripretinib and work with Market Insights to implement appropriate studies
• Analyze customer insights, monitor brand performance and competitive dynamics to inform/adjust marketing/brand strategy and address customer needs
• Monitor and measure the success of personal and non-personal promotion and recommend modifications/adjustments as appropriate to ensure highest ROIs
• Evaluate new market segments and competitive landscape to identify and recommend emerging opportunities
• Work closely with Sales/Sales Training to ensure promotional messaging implementation and a highly actionable national sales meeting/POA meeting execution
• Collaborate with Medical Affairs and provide input on studies, publications and in the identification and engagement of KOLs (primarily at Institutional and Community level)
• Align with Market Access colleagues to develop impactful/actionable market access/payer strategy and tactics
• Be comfortable in interfacing with/presenting to senior leadership to update them on product performance and other critical information
• Oversee two direct reports to ensure commercial success for ripretinib and provide coaching/mentoring to develop talent pool for the company
• Be the change agent that will help build and maintain the culture as Deciphera transitions from a development stage company to a successful commercial company
• Role involves significant travel (approximately 30% of time) to medical meetings, sales meetings, market research, etc.

Qualifications:
• Proactive, results oriented, self-starter motivated by the desire to do the right thing for the patients and their caregivers
• Bachelor’s degree in a business-related and/or life sciences field required from an accredited school. An MBA or advanced degree preferred but not necessary
• 10+ years of Marketing and related experience in the pharmaceutical industry
• Extensive knowledge of medical, regulatory, legal review process
• Oncology/Launch experience is a must
• Comfortable working in a fast paced, constantly evolving start-up environment
• Excellent people management skills – not only with direct reports but also with cross functional partners and broader organization and outside agencies
• Demonstrated ability to multi-task, show attention to detail and follow-through to completion
• Strong team player and a change agent who further reinforces/enhances Deciphera’s cultural values
• Bring high level of innovation and creativity
• Demonstrated analytical and problem-solving skills
• Excellent written and verbal communication skills
• Demonstrated track record of commercial success in positions with progressive responsibilities
• Must be a true team player – authentic, humble, able to build a positive team spirit and lead through the ups and downs of drug development, puts success of team above own interests and support everyone’s efforts to grow and develop
• Ability and willingness to work effectively and seamlessly at multiple “altitudes” within the organization. Maintains a “no job is too big or too small” attitude necessary to succeed in a startup environment
• Must adhere to Deciphera’s core values, policies, procedures and business ethics

This is a wonderful opportunity to join Deciphera’s select team in a leadership position and become part of an emerging success story that is driven by the company’s unwavering commitment to patients and to its employees. Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Director, Market Access Strategy and Marketing

Job #: :03-222

Reports to: Vice President, Market Access

Location: Waltham, MA

Company Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality and durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:
• Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• Surrounded by diverse, multi-disciplinary, dedicated and talented workforce who are passionate about achieving excellence in all they do
• Driven by a work environment that allows employees to balance their priorities
• And above all else, focused on doing the right thing for the patients and their caregivers

Our Drug Discovery Engine – Kinase Switch Control Platform
Our proprietary drug discovery platform is based on our deep insight into the biology of kinases, which are regulated by control of their shape, or conformation. The transformation of a kinase from an inactive to an activated state is dependent upon the interaction of one region of the kinase called the activation switch with an area called the switch pocket; a mechanism of activation that is common among all kinases. While this activation mechanism is common among kinases, the molecular structure of the activation switch and the switch pocket varies. At Deciphera, we take advantage of this activation mechanism by engineering inhibitors that selectively bind the switch pocket, preventing activation of the kinase. By directly targeting the switch pocket, we can engineer novel kinase inhibitors that are highly selective but also broadly active against the target kinase, covering both wild-type and many or all known mutant or amplified forms.
We believe no other kinase inhibitors on the market or active in clinical development directly target the switch pocket region, making Deciphera the only biopharmaceutical company that is currently developing kinase inhibitors using this approach. Our kinase switch control inhibitors interact at a molecular level in a way that is distinct from other kinase inhibitors and are designed to generate higher and more durable rates of response. Using our kinase switch control inhibitor platform, we have developed a diverse pipeline of differentiated, wholly owned, orally administered drug candidates that include three clinical-stage and two research-stage programs.

Position Summary:
The Director, Market Access Strategy and Marketing is a newly-created role within Deciphera’s Commercial organization. This role reports to the Vice President of Market Access and it will have a tremendous impact in bringing Deciphera’s first oral cancer therapy to market for patients with gastrointestinal stromal tumors (GIST).
The Director, Market Access Strategy and Marketing will lead development of a comprehensive reimbursement, pricing, health economic value and access strategy to ensure success of the company’s oral oncology therapies. The Director will focus at all times on how to reduce real and perceived barriers to access and ensure that patients receive the Deciphera therapies they have been prescribed. He/she will be responsible for working closely with internal stakeholders to include but not limited to finance, legal, accounting, operations, payer field team, patient support services and HEOR.

Responsibilities:
Access Strategy
• Develop cross functional market access strategies that tie together all aspects of reimbursement, pricing, health economic/value and commercial distribution of the company’s therapies.
• Apply deep understanding of national and local reimbursement trends, policies, guidelines, and evolving health care delivery models to develop access strategies with commercial and government payers, IDNs, and other account segments such as OCM providers.
• Monitor state and federal policy and market reimbursement trends to ensure Deciphera’s access strategies evolve appropriately, are innovative and compliant.
• Understand and communicate how changes in the reimbursement and policy environment can impact Deciphera’s development plans, sales execution, financial forecasting, and corporate messaging.
• Be a key partner to the Deciphera legal team to ensure that risk profile of access programs is understood.
• Lead innovation in the access and reimbursement space for Deciphera’s therapy’s; bring new ideas forward that will enhance the company’s reputation with payers, patients, and providers as a partner in the access space.
• Be the internal expert in access policies issues and work with relevant internal stakeholders to understand the implications; be prepared to advocate how to engage the environment to successful improve patients access to therapy.
Access Marketing
• Lead development of US value messages to communicate the story of Deciphera’s therapy’s to payers, healthcare providers, patients and other decision-makers.
• Develop marketing materials for field-based reimbursement teams to improve customer and patient access and help payers recognize the economic burden of disease in GIST and the value of Deciphera therapy’s and solutions.
• Create support materials for patients and providers outlining hub and other patient support offerings and channel options; development of materials across all channels; personal and non-personal, web and print.
• Develop access marketing materials to support pull-through of coverage with field sales teams.
• Identify the need for, and drive the selection of, external agency partners. Manage agency partners for creation of access materials and affordability solutions for on-time delivery within scope/budget.
• Be the content expert working in partnership with the head of training and development to broaden the understanding of access challenges and opportunities to the broader internal stakeholders.
• Lead development of external access and pricing messaging to non-customer stakeholders like investors, media, and government agencies.
General
• Determine best approach to National organizations (e.g. ACCC, COA, NCODA), payer organizations (AMCP, PCMA, etc.) and state societies (e.g. FLASCO and MSHO) and lead efforts to partner with these organizations.
• Build effective working relationships with key external advisors in partnership with Medical Affairs and patient organizations in partnership with the Head of Patient Advocacy.
• Partner closely with the Director of Patient Support Services, to ensure patient needs are understood and there is alignment of affordability programs with access strategies.
• Partner with Deciphera’s Legal Team ensure compliance to applicable laws and regulations.

Qualifications:
• Proactive, results oriented, self-starter motivated by the desire to do the right thing for the patients and their caregivers
• 10+ years of working in the pharma/biotech space, with at least 5+ years working in market access.
• In-depth knowledge of managed care and impact on therapy access as with external partners and vendors.
• Strong oral and written presentation skills and executive presence.
• Oncology and/or Rare disease experience desired.
• Ability to work in a fast-paced, highly visible and dynamic environment is critical; able to work effectively with ambiguity and incomplete information.
• Ability to influence and lead across functions; operate in a matrix environment.
• Must be a true team player – authentic, humble, able to build a positive team spirit and lead through the ups and downs of drug development, puts success of team above own interests and support everyone’s efforts to grow and develop
• Ability and willingness to work effectively and seamlessly at multiple “altitudes” within the organization. Maintains a “no job is too big or too small” attitude necessary to succeed in a startup environment
• Must adhere to Deciphera’s core values, policies, procedures and business ethics

This is a wonderful opportunity to join Deciphera’s select team in a leadership position and become part of an emerging success story that is driven by the company’s unwavering commitment to patients and to its employees. Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Director, Distribution and Channel Strategy

Job #: :03-221

Reports to: Vice President, Market Access

Location: Waltham, MA

Company Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality and durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:
• Providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• Surrounded by diverse, multi-disciplinary, dedicated and talented workforce who are passionate about achieving excellence in all they do
• Driven by a work environment that allows employees to balance their priorities
• And above all else, focused on doing the right thing for the patients and their caregivers

Our Drug Discovery Engine – Kinase Switch Control Platform
Our proprietary drug discovery platform is based on our deep insight into the biology of kinases, which are regulated by control of their shape, or conformation. The transformation of a kinase from an inactive to an activated state is dependent upon the interaction of one region of the kinase called the activation switch with an area called the switch pocket; a mechanism of activation that is common among all kinases. While this activation mechanism is common among kinases, the molecular structure of the activation switch and the switch pocket varies. At Deciphera, we take advantage of this activation mechanism by engineering inhibitors that selectively bind the switch pocket, preventing activation of the kinase. By directly targeting the switch pocket, we can engineer novel kinase inhibitors that are highly selective but also broadly active against the target kinase, covering both wild-type and many or all known mutant or amplified forms.
We believe no other kinase inhibitors on the market or active in clinical development directly target the switch pocket region, making Deciphera the only biopharmaceutical company that is currently developing kinase inhibitors using this approach. Our kinase switch control inhibitors interact at a molecular level in a way that is distinct from other kinase inhibitors and are designed to generate higher and more durable rates of response. Using our kinase switch control inhibitor platform, we have developed a diverse pipeline of differentiated, wholly owned, orally administered drug candidates that include three clinical-stage and two research-stage programs.

Position Summary:
The Director, Distribution Strategy and Channel Management is a newly-created role within Deciphera’s Commercial organization. This role reports to the Vice President of Market Access and it will have a tremendous impact in bringing Deciphera’s first oral cancer therapy to market for patients with gastrointestinal stromal tumors (GIST).
The Director, Distribution Strategy and Channel Management is responsible for the development and execution of Deciphera’s channel and distribution strategy. He/she will be responsible for negotiating, managing, and implementing all distribution contracts and fee for service agreements within the channel. He/she will be responsible for working closely with internal stakeholders including but not limited to finance, legal, accounting, operations, access field team, and marketing.

Responsibilities:
• Create the launch distribution model for DCC-2618. Identify all possible distribution options, weigh costs, benefits and challenges, and present recommendations. Must consider all aspects from 3PL, specialty distribution, specialty pharmacy, in-office dispensing, etc. and provide a comprehensive and strategic solutions for implementation.
• Define & create business relationships across all contracted and non-contracted wholesale, distributer, and pharmacy accounts.
• Negotiate any contracts for the trade channel ensuring contracts align to commercial goals and lead implementation of agreements once signed.
• Proactively oversee the management of the day-to-day operations of Deciphera’s distribution and channel.
• Direct and implement distribution channel strategy improvements that increase service levels to end customers and patients; analyze program data and market dynamics and recommend programs to improve the overall platform for all customers.
• Bring an analytic rigor to the channel management function; assist the commercial business in making data driven decisions to improve access, sales and the patient experience.
• Manage Order to Delivery cycle activities to ensure contractual requirements (i. e. inventory levels, data delivery and service levels) are met and financial implications are communicated.
• Create weekly process for understanding forecast, demand, and supply needs; partner with supply chain to ensure adequate product is available through channel.
• Prepare and conduct quarterly business reviews with all trade partners in partnership with key internal stakeholders.
• Liaise with field-based teams and internal customers on data and distribution reporting questions to provide answers and resolve inquiries as received including serving as the main point of contact for distribution-related issues
• Incorporates marketplace, industry trends, customers, and competitors to develop a clear vision for channel segment.
• Evaluate competitive activity and identify key opportunities to seek advantage with the channel strategy.
• Establish key metrics for our channel partners and hold them accountable to service level standards while nurturing strong partnerships.
• Develop and implement channel policies and procedures, such as: orders, returns, replacements, credit/rebill requests, inventory, and chargeback processing.
• Stay abreast of industry standards and FMV rules.
• Partner closely with the Director of Patient Support Services to ensure patient needs are met by current channel design.
• Design and develop data strategies that enable Deciphera to identify trends and opportunities to improve distribution efficiencies and outcomes.
• Partner with Deciphera’s Legal Team ensure compliance to applicable laws and regulations.

Qualifications:
• Proactive, results oriented, self-starter motivated by the desire to do the right thing for the patients and their caregivers
• Bachelor’s degree required. MBA preferred
• 10+ years of working in the pharma/biotech space, with at least 5+ years working with wholesale/specialty distributors and specialty pharmacies, specifically setting channel strategy and pulling through contracts.
• Experience with oral oncology or rare oral therapy.
• Outstanding relationships with channel partners, pharmacy customers, and service vendors.
• In-depth knowledge of managed care and impact on product access as with external partners and vendors.
• Strong oral and written presentation skills and executive presence.
• Ability to work in a fast-paced, highly visible and dynamic environment is critical; able to work effectively with ambiguity and incomplete information.
• Ability to influence and lead across functions; operate in a matrix environment.
• Must be a true team player – authentic, humble, able to build a positive team spirit and lead through the ups and downs of drug development, puts success of team above own interests and support everyone’s efforts to grow and develop
• Ability and willingness to work effectively and seamlessly at multiple “altitudes” within the organization. Maintains a “no job is too big or too small” attitude necessary to succeed in a startup environment
• Must adhere to Deciphera’s core values, policies, procedures and business ethics

This is a wonderful opportunity to join Deciphera’s select team in a leadership position and become part of an emerging success story that is driven by the company’s unwavering commitment to patients and to its employees. Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Medical Science Liaison (MSL)

Job #::02-264

Job Title: Medical Science Liaison (MSL)

Location: Remote/Field Based (12 Locations)

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking a Medical Science Liaison (MSL), field-based scientific/clinical experts that will report to a Regional Director of MSLs within the Medical Affairs (MA) department. The MSL is a highly trained professional with strong clinical and/or scientific backgrounds who must have excellent communication skills. The MSL is responsible for identifying, developing and managing relationships with current and future Healthcare Providers(HCP’s) in academic and community practices.
This position is available as a remote position from home and will have significant expectations for travel.

Key Responsibilities:
• Exchange complex medical & scientific information with the oncology community.
• Develop valued and productive scientific relationships with Opinion Leaders (OLs) and other disease experts.
• Provide medical/scientific presentations to internal & external groups.
• Provide internal Medical stakeholders with feedback and insights from interactions and discussions with HCPs.
• Assist with awareness of company-sponsored clinical trials and investigator-initiated trials (ISTs).
• Provide support at professional meetings, including staffing exhibits, collecting competitive intelligence and developing tools that support the function.
• Adhere to corporate and healthcare compliance guidance in all activities, including those related to clinical trials, scientific interactions with internal and external groups, and responses to unsolicited requests for medical/scientific information.
• Maintain clinical, scientific, and technical expertise in specific therapeutic areas; review scientific journals, attend scientific and key technical meetings.
• Represent the company and Medical Affairs during exchanges with the medical/scientific community.
• Establish and maintain ongoing long-term collaborative peer-to-peer relationships with Oncologists, and other HCPs within their assigned territory.
• Respond to and document unsolicited requests for scientific information for Deciphera’s programs and other products, including those in development.
• Engage with assigned Medical Groups to support their scientific and research needs as consistent with Deciphera’s Medical Affairs strategy.
• Collaborate with publication planning to support development of publications and communications.
• Facilitate investigator interactions with Medical Directors and other internal stakeholders.
• Provide clinical input and training to internal functions within regulatory guidelines.
• Provide support for content development and delivery of clinical presentations at Advisory Boards.

Required Qualifications:
• PharmD, PhD or RN with advanced degree preferred.
• 5+ years of experience in oncological malignancies, preferred.
• 5+ years of experience as field-based MSL, preferred.
• 8+ years of experience in industry (e.g., biotech/pharmaceutical/medical device company, Contract Research Organization), academic research, or public health preferred.
• Experience with clinical research, publication activities, congress/conference and presenting scientific data.
• Experience functioning as a field-based employee preferred.
• Training and/or knowledge of Good Clinical Practice (GCP) and global regulations
• Ability to effectively build relationships and work with global KOL’s.
• Think strategically; apply knowledge and analytical skills in a highly regulated environment; and align medical and commercial strategies
• Ability to summarize complex information and present in a clear, concise, and scientifically accurate manner to a range of audiences
• Knowledge of ICH guidelines, FDA Drug Regulations with respect to DDMAC, PhRMA Principles on Conduct of Clinical Trials and Communication of Clinical Trial Results, and OIG Compliance Program Guidance for Pharmaceutical Manufacturers.
• Excellent communication skills
• Strong problem solving, decision-making, influencing, and negotiation skills.
• Able to travel overnight (up to 60%)

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Regional Director, Medical Science Liaison (MSL)

Job #::02-263

Job Title: Regional Director, Medical Science Liaison (MSL)

Location: Remote/Field Based

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking a Regional Director, Medical Science Liaison who will have regional responsibility for building, leading, managing, and supporting the US MSL field team and will report to the National MSL Director. Together with the National MSL Director and VP of Medical Affairs, the Regional Director, MSL will build the team and establish the long‐term vision, strategy, plans, objectives, and infrastructure for the MSL team. The successful candidate will have significant experience facilitating strong MSL relationships with the external scientific and medical community. The Regional Director, MSL will be accountable for regional execution of the medical affairs program strategy and assure Medical Science Liaison activity execution within expected scope, budget and timelines in support of Deciphera’s pipeline agents. The Regional Director, MSL will also maintain a region of coverage for Key Opinion Leader engagement, to provide medical support for the brand plans, to support development strategies and initiatives for Deciphera’s programs and advance the body of scientific knowledge.
This position is available as a remote position from home and will have significant expectations for travel.

Key Responsibilities:
• Build, lead and manage a regional field – based team of scientific professionals in their successful delivery of medical education and support of Investigator Initiated clinical trials in Oncology.
• Identify candidates, hire, train, develop, and manage a team of MSLs to implement field initiatives ensuring the development of best practices and scientifically‐based materials that are compliant with all legal and regulatory and company guidelines.
• In collaboration with key internal stakeholders, lead the development and execution of Deciphera’s external engagement and educational strategies for centers of excellence, HCP’s, and thought leaders.
• Lead medical education through communication of scientific information.

• Ensure high quality presentations of scientific data in various settings, including advisory boards, investigator meetings, to enhance product/disease state knowledge.
• Provide support to clinical operations for investigators in ongoing clinical trials, investigator-initiated research, and registries consistent with company objectives and regulations.
• Lead Deciphera’s medical team at national and regional scientific meetings including staffing medical affairs booths, gathering competitive intelligence, and developing pre and post‐conference scientific materials.
• Identify key deliverables, insights, and metrics that highlight the value of the MSL organization and communicate with senior leadership at Deciphera on an ongoing basis.
• Track and provide quantitative and qualitative data from MSL activities that demonstrate customer impact to the Deciphera organization and ensure goal achievement.

Required Qualifications:
• PharmD, PhD, or MD preferred. Advanced degree Nurses, NPs, PAs, or those with a Master’s degree in life sciences with pharmaceutical industry and clinical research experience are also welcome to apply.
• Exceptional leadership/management skills; prefer 5 years of experience leading field based MSL teams.
• Thorough understanding of applicable federal and state regulatory requirements for field‐based scientific personnel; successful track record of compliance.

• Experience/expertise in interpretation of scientific data, market research, competitive intelligence tools, drug information systems, and developing medical educational strategies.

• Outstanding written and verbal communication/listening and presentation skills.
• Previous success translating/tailoring complex scientific concepts into simple language for targeted audiences.

• Demonstrated problem solving abilities and strong organizational skills.
• History of collaboration/teamwork; reputation for successful partnering with internal and external stakeholders, including medical opinion leaders, large group practices, medical directors and MCO professionals.

• Good understanding of clinical development and commercial environment.
• Ability to work successfully in a team/matrix environment and independently, as required.
• Pragmatic, solution-oriented thinker who possesses a “can do” and” whatever it takes” attitude, coupled with excellent organizational and communication skills.

• Strong interpersonal skills with the ability to motivate and influence others, negotiate during situational conflict, and establish the best forward path in the face of competing points of view.
• Proficiency with Veeva and Microsoft Office; in depth Word, PowerPoint & Excel skills.
• Ability to travel (60%).

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Medical Director, GIST

Job #::02-262

Job Title: Medical Director, GIST

Location: Waltham, MA

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking a Medical Director for our Medical Affairs team in the Home office. The Medical Director plays a pivotal role and provides clinical expertise to the GIST therapeutic area and will work closely with a cross functional team. This position will report directly into the Vice President, Medical Affairs.

Key Responsibilities:
• Leading GIST Medical Affairs activities in the pipeline.
• Developing and executing a highly efficient, integrated global medical affairs/scientific strategy, including scientific evidence generation.
• Providing relevant data evidence to ensure that the strategy is clearly defined and consistent with clinical development and commercial strategic objectives and activities for selected products and initiatives.
• Reviewing and approving medical and scientific content of Regulatory, Safety, Scientific Affairs, Medical Affairs, and Commercial.
• Ensuring that all data on GIST programs generated by the company or investigator sponsored trials is publicly presented in an appropriate and timely fashion and in a fair and balanced manner.
• Working closely with and influencing clinical development on all aspects, including study design, initiation, and monitoring.
• Providing leadership and strategic direction to local Program Leaders in interactions and communications with external customers, key organizations, and institutions.
Required Qualifications:
• MD with at least 5 years of pharmaceutical or biotechnology industry experience in oncology clinical development OR academic clinical research; Board Certification in Medical Oncology is preferred.
• Industry experience in Medical Affairs is preferred.
• Sound scientific and clinical judgment, including in-depth understanding of the scientific method and clinical applications based on medical, scientific, and practical rationale.
• Prior experience and strong history of relationships with academic investigators.
• Strong communication skills and executive presence.
• Strong interpersonal skills with the ability to motivate and influence others, negotiate during situational conflict, and establish the best forward path in the face of competing points of view.
• Proficiency with Veeva and Microsoft Office; in depth Word, PowerPoint & Excel skills.
• Ability to travel (60%).

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Sr Manager/Assoc Director, Global Health Economics and Outcomes Research (HEOR)

Job #:02-259

Job Title: Senior Manager/Associate Director, Global Health Economics and Outcomes Research (HEOR)

Location: Waltham, MA

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
This position will report to the VP Health Economics & Outcome Research and Market Access and be located in the Waltham office.

Key Responsibilities:
• Support development of clear, compelling and differentiating payor value messages for our medicines
• Provide input into clinical plans regarding HEOR endpoints and ensure follow-up during trials to ensure accurate and complete collection of HEOR data
• Develop and maintain strong relations with Market Access, Business Analytics, and Statistics groups
• Work with cross-functional partners to develop thoughtful and informative insights regarding the economic consequences and impact to patient-outcomes of Deciphera’s products, in a way that is aligned to the objectives of Deciphera
• Leverage research findings to develop tools useful for payors and other stakeholders (e.g., budget impact models, cost-effectiveness models, survival models)
• Leverage data such as: longitudinal electronic medical records, pharmacy data, and medical claims
• Pursue excellence in quality of design, execution and publication of real-world health outcomes studies for ripretinib and the pipeline
• Ensure compliance with regulatory and legal policies when conducting and disseminating research
• Assume overall accountability for vendor deliverables
• Collaborate with field force to maintain an updated HEOR tool kit and dossier and anticipate the evolving payor response to ripretinib
• Periodically train colleagues such as the account management team, field force and global teams on HEOR results, value messages, and tools, and serve as a valued and responsive resource to them
• Work to disseminate results in a suitable format, such as dossiers, manuscripts, posters and Excel tools
• Ensure compliance with regulatory and legal policies when conducting and disseminating research
• Participate in projects unrelated to HEOR, as the need arises

Required Qualifications:

• Graduate degree required; formal training in economics, epidemiology, physics, statistics, health economics, outcomes research, health services research, or other similarly relevant field of study with emphasis on useful mathematical modeling
• Strong analytical skills including experience in designing and creating mathematical models of complex systems
• Experience using VBA, Matlab, R, or SAS

Preferred Qualifications:
• Additional helpful experience and skills
• Understanding of regulatory standards for communication of health outcomes data in the US
• Previous HEOR experience in the pharmaceutical/biotech industry
• Past roles in strategy, account management or other business planning role
• A cross-functional orientation and ability to partner with colleagues
• Results-orientation with excellent interpersonal, communication and presentation skills
• Travel is expected to be less than 10% on average, but may be frequent around product launch
• Strong commitment to business ethics and teamwork

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Vice President, Corporate Development and Alliance Management

Job #::03-217

Job Title: Vice President, Corporate Development and Alliance Management

Location: Waltham, MA

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking a Vice President of Corporate Development and Alliance Management to lead and manage the company’s corporate partnerships and alliances from the research phase through clinical development and into commercialization. The strategic and pivotal nature of this role requires an individual who can effectively and efficiently partner with the Chief Business Officer (CBO) and across the Executive Management Team to maximizing the strategic value of the Company’s portfolio of drug product candidates. While a strong deal sheet of successfully completed transactions will be an important factor in selecting the individual for this new role, the ability to identify, assess and understand the nuances required to craft transactions that build long term value is a critical capability.

This position will report to the Chief Business Officer and be located in the Waltham, MA office.

Key Responsibilities:
• Design and execute partner outreach campaigns, and drive discussions to identify potential partnering and M&A opportunities that support of the Company’s strategic goals and maximize the value of the Company’s portfolio of drug product candidates.
• Lead and inspire cross-functional teams to evaluate partnership opportunities and undertake due diligence to industry leading standards.
• Develop appropriate deal structures, term sheets, benchmarking and valuation models to assess and inform both the evaluation of opportunities and subsequent negotiations.
• Communicate effectively and timely with the CBO and the Executive Management Team regarding the status, timing, key events, and revisions to corporate development activities.
• Create agendas, minutes, materials and dashboards to support and communicate corporate development activities.
• Prepare and present information and materials to the Executive Management Team and potentially to the Board of Directors on potential partnership opportunities.
• Work with the CBO and legal counsel to develop negotiation strategies and positions, draft and review term sheets and contractual agreements, and lead negotiations to closure.
• Manage existing alliances, including their governance structures and mechanisms for dispute escalation.
• Continuously assess and benchmark the Company’s corporate development and alliance management practices and activities to ensure that these are at industry leading standards.
• Participate in Portfolio Strategy Steering Committee and Program Team Meetings as the key representative from Corporate Development.

Required Qualifications:
• B.S./M.S. degree in a life sciences discipline; advanced degree and/or MBA strongly preferred.
• A minimum of 15 years relevant experience in the biopharmaceutical industry, including a minimum of 10 years transactional experience in business/corporate development.
• A strong network of business development contacts within the biotechnology and pharmaceutical industry.
• Deep understanding of the drug development process, including strategic and operational aspects; significant experience within oncology strongly preferred.
• Deal sheet and proven track record of successfully leading, negotiating and delivering high value corporate partnerships and/or M&A.
• Strong analytical skills with a thorough understanding of financial evaluation techniques (commercial forecasting, deal analyses, P&L modeling, NPV, etc.).
• Self-directed, accomplishment-driven individual with a strong sense of passion and urgency who can work both independently and in a cross-functional team environment, fostering open communication, mutual understanding and cooperation.
• Pragmatic, solution-oriented thinker who possesses a “can do” and ”whatever it takes” attitude, coupled with excellent organizational and communication skills.
• Strong interpersonal skills with the ability to motivate and influence others, negotiate during situational conflict, and establish the best forward path in the face of competing points of view.
• Proven ability to be productive and successful in an intense work environment.
• Ability to articulate complex issues and ideas with clarity.
• Ability and willingness to undertake significant travel.
• Fluency with standard computer software packages (MS Word, Excel, PowerPoint, and Project). Experience with deal valuation tools and/or software applications is a plus.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Associate Director, New Product Planning

Job #::03-216

Job Title: Associate Director, New Product Planning

Location: Waltham, MA

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking an Associate Director/ Director, New Product Planning who will drive key business decisions by providing data driven strategic input to shape the early commercial strategy of preclinical- and early clinical-stage assets across the company’s pipeline of novel kinase switch control inhibitors. This new position will collaborate closely across functions within the organization including research, development, program management, clinical development, clinical operations, regulatory, business development, and commercial. The role offers a candidate the opportunity to significantly contribute to the long-term commercial success of the portfolio, and is responsible for providing commercial input and evaluation into key early stage product planning opportunities, and includes early market research and business intelligence activities, as well as initial competitive positioning and preferred product presentation. The ideal candidate should have experience working in product marketing, business intelligence or commercial analytics within a biotech or pharmaceutical company. While the position reports to the Chief Business Officer, the role requires particularly close collaboration with the commercial group reporting into the Chief Commercial Officer.

This position will report to the Chief Business Officer and be located in the Waltham, MA office.

Key Responsibilities:
• Work cross-functionally with the various program teams to conduct robust and rigorous market assessments on key oncology disease areas and the opportunities for pre-clinical- and early clinical-stage assets.
• Provide commercial input and strategic guidance to cross-functional program teams to inform key business and development decisions.
• Communicate key disease area/market insights to relevant internal stakeholders, identifying considerations and implications for Deciphera’s pipeline plans.
• Identify gaps in internal understanding of target diseases and create and execute plans to address gaps through primary and/or secondary market research.
• Construct validated market assessments and forecasts for potential label indications for pre-clinical- and early clinical-stage assets.
• Develop and propose early commercial strategies, value propositions and a prioritized approach to potential label indications.
• Collaborate with internal stakeholders (primarily the commercial group) to develop, update and maintain Target Product Profiles (TPPs) for Deciphera’s early oncology assets.
• Develop and maintain early asset dashboards for communications to Senior Leadership on visions, strategies, opportunities, challenges, risks and tactical activities for Deciphera’s early oncology assets.
• Develop and maintain strong, internal partnerships with cross-functional colleagues (e.g. commercial, regulatory, CMC, clinical, business development, research etc.).
• Provide commercial input on business development asset evaluations.
• Participate in the various program team meetings for Deciphera’s early oncology assets.

Required Qualifications:
• B.S./M.S. degree in a life sciences discipline; an MBA strongly preferred.
• A minimum of 6-8 years relevant commercial experience in the biopharmaceutical industry including a minimum of 3-4 years new product planning or equivalent experience in oncology.
• Strong understanding of the drug development process in oncology including the strategic and operational requirements.
• Ability to synthesize findings and clearly articulate implications from multiple sources of information, including primary and secondary market research and data, and formulate strong, supportable recommendations.
• Self-directed, accomplishment-driven individual with a strong sense of passion and urgency who can work both independently and in a cross-functional team environment, fostering open communication, mutual understanding and cooperation.
• Pragmatic, solution-oriented thinker who possesses a “can do” and ”whatever it takes” attitude, coupled with excellent organizational and communication skills.
• Proven ability to be productive and successful in an intense work environment
• Fluency with standard computer software packages (MS Word, Excel, PowerPoint, and Project). Experience with forecast and valuation models and/or software applications a plus.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Contracts Manager

Job #: :03-215

Job Title: Contracts Manager

Location: Waltham, MA

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking a contracts professional to join our growing legal team. This person will manage contracts and serve as a business partner for various departments. Under the supervision of the Associate General Counsel, this individual will work with the business to identify and mitigate legal risk and manage a variety of contracts. This is an exciting opportunity to both build and manage the contracting needs of a growing biotech company.

This position will report to the Associate General Counsel and be located in the Waltham, MA office.

Key Responsibilities:

• Evaluate and effectively manage business timelines and goals to ensure quality legal support.
• Collaborate with business functions, including finance, regulatory, supply chain and program management to manage various legal initiatives, contracts, and other projects through completion.
• Responsible for building, managing and implementing the contract process from beginning to end, including communicating and corresponding with internal clients, vendors and other stakeholders, drafting contract language, negotiating with external parties, and ensuring proper tracking, execution and filing of contracts.
• Draft, review, and negotiate a wide variety of agreements, including confidential disclosure agreements, clinical trial agreements, master services agreements, consulting agreements, quality agreements, and work orders.
• Correspond, communicate, and build relationships with internal clients, CROs and vendors.
• Identify and address legal and compliance risks and find solutions to mitigate these risks.
• Assist with the selection and implementation of contracts management database.

Required Qualifications:

• Bachelor’s degree required.
• Excellent execution and follow through skills.
• Experience drafting and negotiating legal language in transactional agreements, some experience with master service agreements and/or consulting agreements preferred.
• Demonstrated expertise in either managing clinical trial agreements or supporting clinical operations functions and clinical study-related issues.
• Experience in a commercial organization strongly preferred.
• Minimum 8 years’ experience working with contracts.
• Outstanding attention to detail and ability to identify business and legal issues.
• Excellent analytical, organizational, and project management skills.
• Manage special projects and performing other duties as assigned by attorneys.
• Perform all other related duties as assigned.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Associate Director/Director, Analytical Development

Job #:04-210

Job Title: Associate Director/Director, Analytical Development

Location: Lawrence, Kansas

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:
• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking an Associate Director/ Director, Analytical Development to have overall responsibility for leading and managing early-stage CMC development activities related to analytical characterization of products/processes and the development, qualification, transfer and validation of analytical methods for QC release and stability testing of small-molecule drug substance, drug product, intermediates, starting materials, excipients, and packaging materials and components. Operating within a virtual (100% outsourced) business model, the incumbent will have accountability for analytical CRO/CDMO selection and oversight. The successful candidate will also assume a key leadership role in the development, review and approval of Module 3 sections of CTD regulatory submissions, written responses to regulatory authorities, and TPP/QTPPs.

This position will report to the Vice President, Chemical and Pharmaceutical Development and be located in the Lawrence, KS office.

Key Responsibilities:
• Working through CDMOs, Lead and manage analytical activities for GMP and non-GMP manufacture of drug substance and drug product, including method development/transfer, method validation, release testing, reference standard characterization, investigations for OOS.OOT results, etc.
• Oversee stability operations and reference standard management for early clinical assets.
• Develop and maintain strong relationships with CRO/CDMO business partners.
• Review/approve technical reports, controlled GMP documents (e.g., analytical methods and associated validation protocols, specifications, change controls, LIRs, SOPs, etc.) and incorporate CMC content for Module 3 CTDs.
• As needed, Represent the Technical Operations organization in meetings with FDA, EMA and related regulatory authorities.

Required Qualifications:
• A B.S./M.S. degree in analytical chemistry or related life sciences discipline with at least 10 years of experience in small-molecule pharmaceutical product development or commercialization (or) a PhD with 5 + years of relevant experience.
• Experience and in depth understanding of routine instrumental methods: HPLC, GC, Mass Spec
• Strong vendor/supplier management skills and excellent communication and cross-functional collaboration skills.
• Competency in developing, implementing and delivering CMC project plans (milestones, timelines, resources, etc.) to successful endpoints.
• Strong decision-making skills and ability to influence internal and external stakeholders.
• Thorough knowledge of the drug development process and ICH requirements for IND/IMPD filings. Track record of authoring and defending Module 3 CTD content.
• Ability to articulate complex issues and ideas with clarity to enable understanding and decision making.
• Ability to work successfully in a team/matrix environment and independently, as required.
• Ability to travel (10%) to CRO/CDMO domestic and international sites.

Preferred Qualifications:
• Prior experience leading and managing small-molecule analytical development in a 100% outsourced environment preferred.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Director, Drug Product Development

Job #::04-209

Job Title: Director, Drug Product Development

Location: Lawrence, Kansas

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:
• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking a Director, Drug Product Development to be responsible for the leadership and management of drug product development and manufacturing activities, including activities at contract research and manufacturing organizations, to support early phase clinical studies. Partnering with drug substance and analytical development teams, this individual will be responsible for the completion of IND-enabling development and drug product manufacturing for small molecule NCEs. The candidate will ensure timely manufacturing of drug product to support early clinical development programs. The Director will further contribute active support for regulatory CMC filings.

This position will report to the Vice President, Chemical and Pharmaceutical Development and be located in the Lawrence, KS office.

Key Responsibilities:
 Design and implement phase-appropriate drug product formulation development and supply strategies to support Deciphera’s pipeline and early clinical programs
 Serve as primary contact and manage CMOs/CROs in conduct of DP process development, process optimization, scale-up and clinical manufacturing.
 Work closely with chemical and analytical development functions
 Provide critical pre- and post-review of manufacturing batch records and integrate results into CMC regulatory filings
 Author and review regulatory reports/documents such as IND filings, IND updates, product development reports, quality summary, master batch records and other key reports/documents
 Potentially represent company in meetings with regulatory agencies
 Work with CMC senior leadership to create and communicate project strategy, plans and schedules that are aligned with company objectives and portfolio prioritization

Required Qualifications:
 Advanced degree (PhD preferred) in scientific or engineering discipline and 10 years of hands-on experience in pharmaceutical industry with drug product development for small molecules
 Experience in solid oral dosage forms.
 Clear written and verbal communication skills. Must be able to communicate effectively with executive leadership, consultants and contract research/manufacturing organizations
 Ability to direct and guide the work of CMOs.
 Understanding of cGMP manufacturing
 Strong project management experience
 Experience in process scale-up and transfer
 Demonstrated ability to multi-task under pressure and ability to prioritize competing activities
 Prior authorship of INDs, IMPDs
 Late stage development and commercialization experience is a plus

Preferred Qualifications:
 Familiarity with US and international regulatory CMC guidance and processes
 Prior experience filing NDAs highly desirable
 Excellent computer skills (e.g., Microsoft Office, Excel, Project)
 Strong organizational skills with attention to detail and ability to manage multiple projects at once
 Ability to work both independently and in a team focused environment
 Ability to travel up to 15% to support CDMO relationships/manufacturing

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Manager/Senior Manager, Clinical Quality Assurance

Job #:02-251

Job Title: Manager/Senior Manager, Clinical Quality Assurance

Location: Waltham, Massachusetts

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking a Manager/Senior Manager, Clinical Quality Assurance to be responsible for the development, maintenance and oversight of GCP activities related to the Clinical Trial activities sponsored by Deciphera. The primary responsibilities will be to ensure that both quality and compliance of Deciphera sponsored clinical trials with respect to Standard Operating Procedures, applicable regulatory requirements (US FDA, ICH, and country specific), along with current industry standards and practices.

This position will report to the Associate Director, Quality Assurance and be located in the Waltham, MA office.

Key Responsibilities:
• Draft, review or revise Clinical SOPs to assess consistency and compliance with regulatory requirements/internal standards
• Attend cross-functional team meetings and provide guidance to clinical operations staff based on interpretation of current regulations to ensure best practices including risk-based management
• Work closely with Clinical Operations to ensure/coordinate appropriate and complete resolution of findings/non-compliant issues, quality investigations, etc. in a timely manner, including approval of corrective action and preventative action (CAPA) plans, as necessary
• Conduct and/or assist in internal audits (systems, processes, vendors, computer system validation)
• Work directly with CRO’s and other external contractors and collaborators, managing the chain of communication related to GCP compliance
• Interact with contract auditors in the scheduling process, kick-off meetings with auditors and internal groups, assist in the drafting of audit plans, confirmation letters and agendas, etc.
• Identify the need for, conduct and/or assist in external audits (includes, but is not limited to, investigator sites, central IRBs, CROs and clinical labs)
• Oversee the audit response process for the Investigator Site and Contract Research Organization (CRO) audits/inspections and ensure acceptability of actions to address findings through the CAPA process
• Provide Quality Control (QC) review of clinical protocols, amendments, Informed Consent Forms, Clinical Study Reports and other clinical trial related documents
• Assist and advise with training QA and clinical staff as necessary for GCP
• Identify potential systemic gaps and coordinate with the appropriate stakeholder to ensure timely remediation
• As appropriate, escalate issues of critical non-compliance and/or lack of urgency in remediation to senior management via the Quality Board
• Perform program specific root cause analysis of compliance issues and provide the appropriate metrics for tracking and trending for the overall QA reporting requirements to functional and senior management
• Assist with inspection readiness, and regulatory inspections as needed

Required Qualifications:
• At least 5 years of direct GCP pharmaceutical/biotechnology experience
• Solid understanding and application of GCP, GLP and ICH requirements, especially ICH E6R2
• A well organized, self-motivated and independent work style with the ability to initiate and follow through on assignments
• Excellent interpersonal skills with knowledge of basic negotiation, influencing and conflict management to assure effective interactions within and across departments
• The ability to simultaneously handle multiple project issues while dealing with time demands, incomplete information, or unexpected events
• Ideal candidate will have broad experience in product development, clinical operations, regulatory compliance and GCP auditing
• A strong team player is required with the ability to effectively communicate sound Quality advice cross-functionally based on experience, regulations & business needs
• Experience with using risk-based principles & decision making to ensure compliance at all stages of development
• Proven track-record of leadership & building relationships with both internal & external customers
• Strong negotiation skills, flexibility & ability to provide a solution-based approach to emerging challenges

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Associate Director/Director, Clinical Scientist

Job #:02-269

Job Title: Associate Director/Director, Clinical Scientist

Location: Waltham, Massachusetts

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
This position may be filled at Associate Director or Director level based on candidate’s skills/experience and will be located at Deciphera’s corporate headquarters in Waltham, MA.

Key Responsibilities:
• Works closely with Medical Directors, Pharmacology, Discovery, external experts, and investigators to accumulate scientific and medical knowledge necessary to support clinical development plans and study designs and protocols
• Assists Medical Directors in creation of proposed concept sheets for clinical studies and may write protocols or work with medical writing to write protocols through incorporation of input from both internal and external experts
• Drives the clinical contribution to annual update of IB liaising with Toxicology, Pharmacology, Safety, Regulatory and Medical & Communication Experts
• Drives and integrates clinical contribution to answering regulatory queries and other submissions related to studies
• Monitors real time study data to ensure the integrity of the study and the study data and interacts with investigators and internal and external experts to resolve any study issues as they arise
• Involved in high level data cleaning activities requiring clinical judgment Involved in analysis of complex data for regulatory submissions, publications and design of studies and programs
• Acts as clinical/scientific expert on the products and studies in the therapy area
• Attends scientific meetings to remain abreast of new developments within relevant areas and to interact with investigators, and advisors
• Works with investigative sites to answer protocol related questions, resolve study conduct and design issues
• May present data, protocol designs and other information at advisory boards, investigator meetings, site initiations and other internal and external settings

Required Qualifications:
• MS in Life Sciences (or BS plus equivalent experience); Pharm D, or BSN or other equivalent clinical qualifications
• 8 years’ experience in product & clinical development (Clinical Scientist role) in Biotech or Pharmaceutical company
• Understanding of GCP, ICH and regional/local regulations
• Experience in both early and late phase development
• Medical knowledge and experience in clinical development/ operations (Oncology preferred)
• Experience reviewing clinical data outputs
• Ability to perform literature searches and to utilize library services
• Ability to conduct basic data analyses using Excel and other tools
• Basic understanding of biostatistics to allow effective interaction with biostatistics expert
• Requires approximately 15-30% travel

Preferred Qualifications:
• Teaching capability
• Excellent communication skills, both verbal and in writing
• Strong presentation skills
• Team player
• Ability to proactively predict issues and solve problems
• Ability to drive decision-making within a multi-disciplinary, multi-regional matrix team
• Diplomacy and positive influencing abilities
• Experience building data presentation plans

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Associate Director, SAS Programmer

Job #::02-249

Job Title: Associate Director, SAS Programming

Location: Waltham, Massachusetts

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:

• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

Position Summary:
We are seeking an Associate Director, SAS Programming to join our biometrics group.
This position will report to the Senior Director, Head of Biometrics and be located in the Waltham, MA office.

Key Responsibilities:
• Serves as a lead programmer for a compound or key NDA related activities
• Efficiently manage CROs to meet timelines and expectation of quality
• Works collaboratively with other functions to ensure clarity, accuracy and consistency of case report forms (CRFs), develop and comply with project/study programming standards and specifications according to regulatory guidelines
• Programs for SDTM data mapping and creation of ADaM datasets and the corresponding specifications according to CDISC standards
• Programs TLFs for implementation of the statistical analysis plans and for AdHoc analysis in clinical trial of all phases
• Performs programming QC on TLFs
• Tracks clinical trial milestones and works with vendors for statistical reporting deliverables.
• Maintains records for all assigned projects and archiving of trial/project analysis and associated documentation
• Understands and performs in accordance with regulatory standards, and drug development principles
• Responsible for the creation and accuracy of Regulatory submission data and clinical summary report package
• Plans, develops, tests, and documents SAS macros for programming efficiency

Required Qualifications
• 8+ years in statistical programming within the Pharmaceutical industry
• Strong understanding of clinical trial processes and statistical programming requirements for regulatory submissions
• Excellent SAS Software Programming skills, including Base SAS, SAS/STAT, SAS/GRAPH and macro development
• Ability to define and implement CDISC compliant SDTM and ADaM data and specifications
• Oncology experience is a plus

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plans, life insurance and a flexible spending account for health care and/or dependent care.

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Manager/Senior Manager, Strategic Clinical Outsourcing

Job #:02-244

Job Title: Manager/Senior Manager, Strategic Clinical Outsourcing

Location: Waltham, Massachusetts

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients. We have used our proprietary drug discovery platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer by enhancing the quality, rate and/or durability of their responses to treatment. We currently retain global development and commercialization rights to our drug candidates, including three programs in clinical development. Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered just outside Boston in Waltham, Massachusetts. Our state-of-the-art research facility is located near the University of Kansas School of Pharmacy in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:
• providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
• a diverse and multi-disciplinary workforce
• dedicated and talented people who are passionate about achieving excellence in all they do
• a work environment that allows you to balance your priorities
• above all else, a commitment to the patients we serve

We are seeking a Manager/Senior Manager, Strategic Clinical Outsourcing to support all clinical outsourcing activities as well as other corporate sourcing activities as requested. The position will work cross-functionally with internal stakeholders such as Data Management, Biostatistics, Translational Medicine, Legal, and Finance. General responsibilities include working with teams to properly assess outsourcing opportunities and provide contractual negotiation support, performance monitoring and follow-up. The successful candidate must be hands-on and comfortable developing procedures, templates, and relationships and work with the Director to contribute to growth and future state of the organization.

This position will report to the Director, Strategic Outsourcing and be located in the Waltham, MA office.

Key Responsibilities:
• Support the outsourcing process and activities for Clinical Development.
• Manage contracting activities including the preparation, finalization, and administration of CDAs, MSAs, Service Agreements, Work Orders, Change Orders, and Amendments while minimizing risk across a broad scope of clinical / therapeutic outsourcing services.
• Assist and/or manage the identification and selection process of clinical vendors such as CROs, central labs, IRT, Imaging, ePRO, Safety vendors, etc.
• Work closely with Clinical Business Operations and Finance to assure the assumptions for studies are aligned between finance and clinical forecasting.
• Meet with clinical trial managers, functional managers, Legal, and QA as needed to ensure vendors are meeting expectations and review progress against contract.
• Create and maintain outsourcing/vendor oversight standards and templates.
• Contribute to the development of an established preferred clinical vendor list.

Required Qualifications:
• Bachelor’s degree with at least five to eight years of experience with a focus on developing and overseeing clinical budgets, and contracts with clinical outsourcing vendors in the pharmaceutical/biotech industry (an equivalent combination of experience and education may be considered)
• At least four years of direct clinical trial and/or vendor oversight experience required; experience negotiating, administering, extending, terminating, and re-negotiating contracts
• Excellent interpersonal, organizational and multi-tasking skills.
• Ability to interface with vendors, collaborators, all internal departments and all levels of management
• Understanding of Clinical/Drug Development; familiar with Regulatory Guidelines including ICH GCP.
• Previous experience working with clinical operations and finance is preferred.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Associate Director/Director, Medical Writing

Job #: – 02-236

Job Title: Associate Director/Director, Medical Writing

Location: Waltham, MA

Role Summary:
Deciphera Pharmaceuticals is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients by tackling key mechanisms of drug resistance that limit the rate and/or durability of response to existing cancer therapies. Our small molecule drug candidates are directed against an important family of enzymes called kinases, known to be directly involved in the growth and spread of many cancers. We use our deep understanding of kinase biology together with a proprietary chemistry library to purposefully design compounds that maintain kinases in a “switched off’ or inactivated conformation. These therapies comprise tumor-targeted agents designed to address therapeutic resistance causing mutations and immuno-targeted agents designed to control the activation of immunokinases that suppress critical immune system regulators, such as macrophages. We have used our platform to develop a diverse pipeline of tumor-targeted and immuno-targeted drug candidates designed to improve outcomes for patients with cancer by improving the quality, rate and/or durability of their response to treatment.

We are seeking an Associate Director/Director, Medical Writing to be responsible for providing Medical Writing leadership for late stage clinical and regulatory affairs activities.

This position will report to the Vice President Regulatory Affairs & Quality Assurance and be located in the Waltham, MA office.

Key Responsibilities:
• Coordinate document development strategies with various functional areas in Clinical Development and Regulatory Affairs to produce high quality work that is compliant with GCP and ICH guidelines
• Act as Lead Medical Writer
• Represent Medical Writing on cross-functional clinical and regulatory teams and actively participate in NDA submission planning and documentation
• Plan and coordinate work with in-house Medical Writers and outside CROs to ensure quality deliverables within assigned time frames

Required Qualifications:
• Experience in development of clinical documents related to late phase studies.
• NDA experience with active contribution in planning and preparation of summary documents is required
• Bachelor’s Degree; Advanced degree (MS or Ph.D.) in a relevant scientific field preferred
• 10+ years of industry experience as a Medical Writer with experience working in a small biopharmaceutical company

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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