TGCT is a locally aggressive neoplasm affecting the synovium of joints, tendon sheaths, and bursae1. TGCT has historically been known as pigmented villonodular synovitis (PVNS) or giant cell tumor of the tendon sheath (GCT-TS)1,2, and can be categorized as either nodular (localized)-type or diffuse-type1. 

For most patients with nodular-type TGCT, surgery can be effective3, with post-surgical recurrence rates varying based on the anatomical location of the tumor1,4. For diffuse-type TGCT cases, surgical technique did not influence functional outcomes in patients with diffuse-type TGCT5 and post-surgical recurrence rates can be as high as 72%6.

TGCT Materials

TGCT disease state Pubvisual video


Registry information

  • TGCT postcard
  • TGCT Study Enrollment Website
     

References

1) Stacchiotti S, et al. Cancer Treat Rev. 2023;112:102491. 
2) Mastboom MJL, et al. Acta Orthop. 2017;88(6):688-94.
3) Gouin F, et al. Orthop Traumatol Surg Res. 2017;103(suppl 1):S91-7.  
4) Mastboom MJL, et al. Interact J Med Res. 2018;7(1):e4.  
5) Mastboom MJL, et al. Lancet Oncol. 2019;20:877-86.  
6) Stern S, et al. Presented at: CTOS Annual Meeting 2024; November 16, 2024; San Diego, CA.