Role of Immunokinases in Cancer

Certain kinases known as immunokinases play a role in the development of cancer through the suppression of the immune system. Tumors suppress immune system cells, such as macrophages and T-cells, essentially shutting off their ability to identify and destroy cancer cells. For instance, tumors may suppress the immune system by sending a signal that activates an immunokinase in immune system cells. The activated kinase then initiates internal signaling within the immune system cells to suppress their function and prevent them from identifying and destroying the cancer cells. A recent development in cancer therapy, referred to as immuno-oncology, uses advances in understanding of the control of the immune system to develop drugs that enhance the ability of immune system cells to recognize and attack cancer cells.

Learn more about our immune-targeted drug candidates rebastinib and DCC-3014.

Kinase Switch Control Inhibitors as Immuno-targeted Therapies

Deciphera’s switch control inhibitors restore the immune system to a strong cancer fighting state by blocking immunosuppressive kinase activation.